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EC number: 293-106-3 | CAS number: 91051-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Eye irritation (OECD 405): not irritating (BASF, 2010)
- RA: 112-63-0: skin irritation (OECD 404): irritating (BASF, 1992)
Key value for chemical safety assessment
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Eye irritation:
The eye irritation potential of the test substance was assessed in a GLP compliant study according to OECD guideline 405 and EU method B.5 (BASF, 2010). Single samples of 0.1 mL of the test substance were instilled into one eye of each of three rabbits. The adjacent eye served as a control. Observations were made 1, 24, 48 and 72 hours after instillation. Instillation of the test substance resulted in redness of the conjunctivae. The irritation had completely resolved within 24 hours in all animals.
Skin irritation:
Methyl linoleate (CAS# 112-63-0) was used as a structural analogue read-across substance for skin irritation hazard identification of Fatty acids, safflower-oil, Et esters. It can be expected that methyl linoleate would exert similar reactions on the skin. Upon activity of dermal esterases, methyl linoleate would be cleaved into linoleic acid and methanol, representing sufficient similarity to the metabolites linoleic acid and ethanol, resulting from cleavage of Fatty acids, safflower-oil, Et esters (CAS# 91051 -53 -5).
The undiluted test substance (CAS# 112 -63 -0, methyl linoleate) was tested for acute dermal irritation (OECD 404, GLP) on the dorsal shaved skin of 3 rabbits in a dose of 0.5 ml. The contact time under semi-occlusive conditions was 4 hours.
Slight to moderate erythema and edema were observed during the first 72 hours after exposure. One week after exposure the skin of all three experiemntal animals showed eschar. The irritation effects of one experimental animal reversed within 7 days. The skin of this rabbit still showed eschar. The observed effects of the other two experimental animals reversed completely within 22 days. The test substance proved to be moderately irritating to the skin according to the conditions applied.
Based on these results methyl linoleate needs to be classified and labelled as skin irritant.
Although no signs of skin irritation were observed in the acute dermal toxicity study, the test substance is classified for precautionary reasons as skin irritant.
Justification for selection of skin irritation / corrosion endpoint:
GLP and guideline compliant study. Methyl linoleate (CAS# 112-63-0) was used as a structural analogue read-across substance for skin irritation hazard identification of Fatty acids, safflower-oil, Et esters (CAS# 91051-53-5). It can be expected that methyl linoleate would exert similar characteristics in skin irriation. Upon activity of dermal esterases, methyl linoleate would be cleaved into linoleic acid and methanol, representing sufficient similarity to the metabolites linoleic acid and ethanol, resulting from cleavage of the test substance (CAS# 91051-53-3).
Justification for selection of eye irritation endpoint:
Most reliable guideline study.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified for eye irritation but is considered to be classified for skin irritation under Directive 67/548/EEC, as amended for the 31st time in Directive2009/2/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is not considered to be classified for eye irritation but is considered to be classified for skin irritation under Regulation (EC) No 1272/2008, as amended for the fifth time in Directive EC 944/2013.
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