Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 691-657-8 | CAS number: 62599-49-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: In-house validated in vitro study, reported as summary, non-GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Direct peptide binding assay (DPRA) performed as described in Bauch C. et al. (2011), Toxicology in Vitro 25, 1162 – 1168.
- Principles of method if other than guideline:
- Binding to Cysteine and Lysine containing model peptides in chemico
- GLP compliance:
- no
- Type of study:
- other: Direct peptide binding assay
Test material
- Reference substance name:
- 2-(2-methylprop-2-en-1-yl)cyclododecan-1-one
- EC Number:
- 691-657-8
- Cas Number:
- 62599-49-9
- Molecular formula:
- C16 H28 O
- IUPAC Name:
- 2-(2-methylprop-2-en-1-yl)cyclododecan-1-one
- Details on test material:
- - Name of test material (as cited in study report): 2-(2-Methylallyl)-cyclododecanon-Rein
- Physical state: Liquid/ colorless, clear
- Analytical purity: 99.3 area-% (not corrected with the water content), Capillary GC-analysis
- Lot/batch No.: 2-(2-Meth-allyl)cyclododecanon (MACD Probe aus B410.16 vom 04.10.2012)
- Storage condition of test material: Room temperature
Constituent 1
In vivo test system
Test animals
- Species:
- other: not applicable
- Strain:
- other: not applicable
- Details on test animals and environmental conditions:
- not applicable
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: not applicable
- Vehicle:
- other: not applicable
- Concentration / amount:
- Test substance was solved at a 100 mM concentration in acetonitrile.
Test substance were incubated with each peptide in ratios of 1:10 (for C-peptide) or 1:50 (for K-peptide).
Challengeopen allclose all
- Route:
- other: not applicable
- Vehicle:
- other: not applicable
- Concentration / amount:
- Test substance was solved at a 100 mM concentration in acetonitrile.
Test substance were incubated with each peptide in ratios of 1:10 (for C-peptide) or 1:50 (for K-peptide).
- No. of animals per dose:
- not applicable
- Details on study design:
- not applicable
- Challenge controls:
- not applicable
- Positive control substance(s):
- yes
- Remarks:
- EGDMA
Results and discussion
- Positive control results:
- The mean Cysteine-peptide depletion, caused by the PC was determined to be 50.7 %.
The mean Lysine-peptide depletion, caused by the PC was determined to be 13.94%.
Any other information on results incl. tables
The mean Cysteine-peptide depletion, caused by the test substance was determined to be 5.61%.
The mean Lysine-peptide depletion, caused by the test substance was determined to be -3.21 %.
No co-elution of test substance and peptides was noticed.
The samples of the test substance with the peptides were emulsions directly after application and after the 24-hour incubation time. Thus
the samples were centrifuged prior to HPLC analysis.
Applicant's summary and conclusion
- Interpretation of results:
- other: Non peptide binding
- Conclusions:
- In a weight of evidence, all present in vitro data on dermal sensitization do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.