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EC number: 209-750-5 | CAS number: 592-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound butyl chloroformate (CAS 592-34-7, rapidly hydrolyzing): No data available.
Hydrolysis product hydrogen chloride (HCL, CAS 7647 -01 -0): Acutely very toxic to aquatic invertebrates (pH dependent).
Hydrolysis product butanol (CAS 71 -36 -3): With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Data for parent compound butyl chloroformate (CAS 592-34-7):
No data on the short-term toxicity to aquatic invertebrates are available for butyl chloroformate (CAS 592-34-7).
However, as the substance rapidly hydrolyses in contact with water to butanol (CAS 71 -36 -3), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). The assessment is, therefore, based on the available data of the hydrolysis products.
Data for Hydrolysis product - hydrogen chloride (HCL, CAS 7647-01-0):
For the hydrolysis product hydrogen chloride (HCL, CAS 7647-01-0) a short-term study with Daphnia magna, performed according to OECD guideline 202 is available (OECD SIDS, 2002). The 48-h EC50 value was determined to be 0.492 mg/L (acid equivalent converted from pH 5.3).
Hydrolysis product – butanol (CAS 71-36-3):
For the hydrolysis product butanol (CAS 71-36-3) a number of results from aquatic invertebrate studies are available. The key effect value is a 48-h EC50 > 1000 mg/L as observed in a study with D. magna. The limit test was conducted according to OECD guideline 202 and in compliance with GLP criteria and the test concentrations were analytically verified (MOE, Japan; 1996). In addition, several acute ecotoxicity studies with freshwater and marine species (D. magna; N. Spinipes; A. salina) are also available for CAS 71-36-3. According to these supporting data the lowest 48-h EC50 was 1328 mg/L, based on measured test concentrations (D. magna; OECD 202; Wong et al. 1998, as cited in SIDS 2001).
No data for the toxicity of carbon dioxide (CAS 124-38-9) to aquatic invertebrates are available.
Assessment:
There are no data available regarding the toxic effect of the parent compound butyl chloroformate (CAS 592-34-7) to aquatic invertebrates.
The key study with the hydrolysis product butanol (CAS 71-36-3) comes from a test with Daphnia magna. The study was performed according to according to OECD guideline 202, the 48-h EC50 was determined to be > 1000 mg/L (nominal), indicating no harmful effects (MOE, Japan; 2002).
The hydrolysis product HCl showed to be acutely very toxic to aquatic invertebrates due to the low pH: 48 -h EC50 = 0.492 mg/L (acid equivalents to pH 5.3; OECD SIDS, 2002).
Summary of acute aquatic invertebrate toxicity data:
Compound |
Species |
Results |
Guideline |
Reference |
Hydrolysis product (CAS 7647-01-0) |
Daphnia magna |
48-h EC50 = 0.492 mg/L (pH-dependent; acid equivalent) |
OECD 202 |
OECD SIDS (2002) |
Hydrolysis product (CAS 71-36-3) |
Daphnia magna |
48-h EC50 > 1000 mg/L |
OECD 202 |
MOE, Japan (1996) |
Hydrolysis product (CAS 71-36-3) |
div. |
48-h EC50 >1000 mg/L |
div. |
OECD SIDS (2001); (summary of div. test results) |
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