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EC number: 231-869-6 | CAS number: 7773-01-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not a standard test method, not to GLP. No data on dose groups etc, not basic observations made. Appears to follow basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum and palladium
- Author:
- Holbrook DJ, Washington ME, Leake HB and Brubaker PE
- Year:
- 1 975
- Bibliographic source:
- Environmental Health Perspectives, 10: 95-101
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two experiments were conducted, a lethal dose experiment and a dietary study.
In the lethal dose experiments salts were administered orally (via stomach tube) or intraperitoneally. The rats were observed through a 14 day observation period. LD50 values were calculated by the method of Litchfield and Wilcoxon.
In the dietary experiments, 4 rats were maintained per cage, the metallic salt under study was dissolved in the drinking water. Animals consumed feed and drinking fluid ad libitum. Analyses for metals were performed on samples from 3 lots of feed. The feed contained 56 ± 5 mg Mn / kg feed. Measurements were made of the body weights of individual rats and feed and fluid consumption per cage of four rats at 7-day intervals during the course of each dietary experiment. At the termination of the dietary experiments, samples of liver were used for the isolation of microsomes. Aniline hydroxylase was measured and modified by the addition of HgCl2. Aminopyridine demethylase was measured. Analyses of rat tissues for Mn concentration was conducted. - GLP compliance:
- not specified
- Test type:
- other: Non standard. LD50 calculated by method of Litchfield and Wilcoxon.
Test material
- Reference substance name:
- Manganese dichloride
- EC Number:
- 231-869-6
- EC Name:
- Manganese dichloride
- Cas Number:
- 7773-01-5
- Molecular formula:
- Cl2Mn
- IUPAC Name:
- manganese(2+) dichloride
- Details on test material:
- Not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals were received at 3 - 3.5 weeks of age and maintained for 1 -1.5 weeks prior to use. The mean body weights were between 100 -110 g at the start of the studies.
Administration / exposure
- Route of administration:
- other: oral gavage and intraperitoneal
- Vehicle:
- water
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7.5 other: mmol / kg
- 95% CL:
- 7 - 8.1
- Remarks on result:
- other: oral gavage
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.7 other: mmol / kg
- 95% CL:
- 0.61 - 0.8
- Remarks on result:
- other: intraperitoneal
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 138 mg/kg bw
- Remarks on result:
- other: calculated from stated value of 0.61 - 0.80 mmol/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 944 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Oral route mg/kg bw equivalent
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- Dietary study:
In rats treated for 90 -91 days, the control rats ingested approximately 0.15 g of manganese (from the solid feed), the tissue concentration of Mn was 1.4 and 1.0 µg Mn/g wet tissue in the liver and kidney respectively. In Mn-treated rats, which received 8.3mM MnCl2 as the drinking fluid and ingested approximately 2.3 g of Mn per rat during the 90 - 91 day interval, the concentration of Mn was increased to 2.8 and 1.6 µg Mn/g of wet tissue on the liver and kidney respectively. The Mn concentration in the spleen, heart, testes and blood was not increased in the tissues of Mn-treated rats.
Lethal dose experiment:
Rats were treated orally with a dose of MnCl2 equivalent to 100% of the oral LD50 value and the tissues were analysed in surviving rats at the end of the 14-day observation period. The oral administration of a single, large but nonlethal dose of MnCl2 to rats did not result in the retention after 14 days of excess concentrations of Mn in any of the tissues analysed. Levels were approximately equal to those found in the control animals.
Applicant's summary and conclusion
- Conclusions:
- Administration via the i.p. and oral route suggested that MnCl2 was harmful to rats. (i.p results indicated an approximate 10-fold higher toxicity than for the oral route).
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