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Diss Factsheets
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EC number: 202-852-0 | CAS number: 100-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This review of toxicokinetics is reliable as it accounts for all the relevant available data in the published and unpublished literature.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Objective of study:
- other: Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Studies and publications were provided to a qualified toxicologist who reviewed the relevant available information and provided an assessment of the likely toxicokinetic behaviour of the substance.
- GLP compliance:
- no
- Remarks:
- not required
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- IUPAC Name:
- 2-vinylpyridine
- Test material form:
- other: liquid
Constituent 1
- Radiolabelling:
- no
Results and discussion
- Preliminary studies:
- 2-Vinylpyridine (2VP) and 4-vinylpyridine (4VP) are considered read-across analogues based on structural similarity; they are isomers. This structural similarity results in their display of similar properties in physical and biological systems. 2VP and 4VP display characteristics of both pyridine and the vinyl group which comprises the constituent group. They display similar physico-chemical properties, environmental fate and ecotoxicity values, and similar toxicological properties. A review of the literature (as available) on 4VP concerning toxicokinetic parameters is not expected to result in different conclusions from that of 2VP.
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Small molecular weight, high water solubility and low octanol/water partition coefficient indicate that the substance is likely to be absorbed in the GI tract and via the skin.
- Type:
- distribution
- Results:
- Small molecular weight and high water solubility indicate that the substance is likely to be distributed in into the water compartment of the body. Skin sensitisation results suggest that the substance can bind to proteins in the blood.
- Type:
- metabolism
- Results:
- Small molecular weight and lack of microbial biodegradation suggest that metabolism may not be necessary to allow excretion from the body.
- Type:
- excretion
- Results:
- Excretion via the kidney is likely significant due to high water solubility and small molecular weight. Any substance which is not absorbed via the GI tract will be excreted in the faeces.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Assessment of the toxicokinetic behaviour of 4VP was undertaken to the extent that can be derived from the relevant available information on a close structural analogue, 2-vinylpyridine. The two substances have very similar physico-chemical and toxicity behaviours and data betweent the two substances can be interchanged for regulatory purposes, such as classification and labeling, PBT and vPvB determination and risk assessment. Critical data include is small molecular weight, high water solubility and low octanol/water partitioning. These data suggest that 4VP is likely to be absorbed via the gastrointestinal tract, distributed in the water compartment of the body, and excreted via the kidneys with or without metabolism. Bioaccumulation and deposition in fat or breast milk is not likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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