Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-707-7 | CAS number: 124-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Two hydrolysis studies of reliability 1 are available and have been defined as key studies. They have been performed with the parent salt of the registered substance; THPS.
The first study (O'Connor, 1992) has been performed in anaerobic conditions, as required by the test method when substances are
known to oxidise.
The second study (Yeomans, 2002) has been performed in non-anaerobic conditions and shows the effect of oxygen on the degradation
properties of THPS main ingredient.
In both test conditions, THPS main ingredient hydrolyses to THPO (Tris(hydroxymethyl) phosphine oxide,CAS No. 1067-12-5) and
formaldehyde (CASNo. 50-00-0).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 6.45 d
- at the temperature of:
- 12 °C
Additional information
Because of the salt nature of THPC, hazard properties of chloride salt could be predicted to be equivalent to hazard properties of the sulphate salt (THPS). In the case of hydrolysis, THPS and THPC follow the same degradation pathway via THP and THPO formation. The read across with THPS is then considered as relevant.
In anaerobic conditions the degradation pathway is believed to proceed via the dissociation product THP (Tris (hydroxymethyl) phosphine, CAS No. 2767-80-8). The formation of THP is favoured as the pH is raised, and the hydrolysis rate constant increases with increasing pH.
In anaerobic conditions, the half lives measured at 25°C were:
131 days at pH=5
72 days at pH=7
7 days at pH= 9
In non-anaerobic conditions, THPS reacts with dissolved oxygen to form THPO and formaldehyde. The degradation rate constants are higher in presence of oxygen, and increase with decreasing pH.
In non-anaerobic conditions, the half lives measured at 20°C were:
1.5 d at pH=5
and 3.4 d at pH=9,
which gives values calculated at 12°C:
2.8 d at pH=5
and 6.45 d at pH=9
THPC is then expected to behave in a similar way:
- in anaerobic conditions, the hydrolysis (and THP formation) is favoured with increasing pH (with half lives in a range of a week at pH9)
- in aerobic conditions, the hydrolysis is faster in acidic conditions (with a half life about 3 days at pH 5)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.