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Diss Factsheets
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EC number: 214-770-2 | CAS number: 1193-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment, basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- Modification of Burton et al (1981), Food and Cosmetic Toxicology, vol. 19, pgs 471-480. This technique ranks materials of known ocular irritation in vivo against % corneal swelling of isolated eyes. A threshold value has been established at 15 % above which a material is considered to cause severe
effects when tested in vivo. - GLP compliance:
- no
Test material
- Reference substance name:
- 4,6-dichloropyrimidine
- EC Number:
- 214-770-2
- EC Name:
- 4,6-dichloropyrimidine
- Cas Number:
- 1193-21-1
- Molecular formula:
- C4H2Cl2N2
- IUPAC Name:
- 4,6-dichloropyrimidine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 10 seconds
- Observation period (in vivo):
- 0.5 h, 1.0 h, 2.0 h, 3.0 h, 4.0 h, 5.0 h
- Number of animals or in vitro replicates:
- two isolated rabbit eyes
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 0.5 h
- Score:
- 6.85
- Remarks on result:
- other: +/- S.DEV 0.66
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 1.0 h
- Score:
- 12.64
- Remarks on result:
- other: +/- S.DEV 2.82
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 2.0 h
- Score:
- 15.98
- Remarks on result:
- other: +/- S.DEV 1.54; threshold value of 15 % exceeded
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 3.0
- Score:
- 15.98
- Remarks on result:
- other: +/- S.DEV 1.54; threshold value of 15 % exceeded
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 4.0 h
- Score:
- 21.62
- Remarks on result:
- other: +/- S.DEV 0.47; threshold value of 15 % exceeded
- Irritation parameter:
- other: Mean % Corneal Swelling
- Basis:
- mean
- Time point:
- other: 5.0 h
- Score:
- 21.62
- Remarks on result:
- other: +/- S.DEV 0.47; threshold value of 15 % exceeded
Applicant's summary and conclusion
- Interpretation of results:
- other: severely ocular irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The TS caused significant corneal swelling to two isolated rabbit eyes after an exposure time of 10 seconds.
The threshold value of 15 % was exceeded after 2 hours. The entire observation time was up five hours.
Although the design of this study does not apply to an established in vitro method and only a very short summary is available instead of a complete report, the study may be regarded as valid with restrictions (Klimisch 2, basic data given) and used for assessment if 4,6-dichloropyrimidine is classified as Xi; R41 (risk ofserious damage to eyes) for precautionary reasons. Regarding the severity of the response obtained in isolated eyes an in vivo study should not be performed due to animal welfare.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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