Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-651-7 | CAS number: 692-49-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Inhalation: OECD 413; rats. NOAEC = 5000 ppm (33548 mg/m3) in males based on test substance-related reductions in body weight and food consumption at 7500 ppm, and 7500 ppm (50322 mg/m3) in females based on no effects observed at the highest concentration tested. Reliability = 1.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 33 548 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 33 548 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Male and female rats were exposed whole body, 6 hours per day, 5 days per week to 0, 3000, 4000, 5000 or 7500 ppm of the test substance over a 90 day period for a total of 65 exposures. Test substance-related adverse effects on body weight and food consumption were observed in male rats exposed to 7500 ppm. Test substance-related, but non-adverse microscopic findings, were observed in the teeth and femur/knee joints of all male and female rats exposed to the test substance. These changes included incomplete decalcification of enamel in the distal region of the upper incisors; no changes in ameloblasts or dentition were observed in the affected animals. Incomplete decalcification of bone trabeculae in the femur was also present in all males exposed but only in females exposed to 7500 ppm; osteoclasts and osteoblasts were morphologically normal. These microscopic findings are consistent with exposure to a fluorine-containing test substance and were not associated with any histopathological changes suggestive of tissue injury or adverse functional consequences in these tissues and, therefore, were not considered to be adverse. The diagnosis of incomplete decalcification refers to a tissue processing phenomenon indicating that metabolism of the parent material includes production of a free fluoride. Thus, “incomplete decalcification” in this and the supporting 90-day study is not a lesion per se but evidence of fluoride exposure. The conclusion of non-adversity for the teeth and bone observations noted in both 90-day studies was based upon the absence of any clinical (abnormal growth or mottling of teeth) or morphological (damage to bone or tooth structure or degeneration of bone/teeth forming cells) changes suggestive of injury or loss of function of these tissues. Under the conditions of this study, the no-observed-adverse-effect-concentration (NOAEC) for the test substance in male rats was 5000 ppm (33548 mg/m3) based upon test substance-related reductions in body weights and food consumption observed in animals exposed to 7500 ppm. The NOAEC for female rats was 7500 ppm (50322 mg/m3), the highest exposure concentration tested in this study.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
OECD guideline, GLP study
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
OECD guideline, GLP study
Justification for classification or non-classification
The NOAEC in male and female rats exposed in a 90-day repeat inhalation toxicity study was 5000 ppm (33548 mg/m3) and 7500 ppm (50322 mg/m3), respectively. Therefore, the substance does not need to be classified for repeated dose toxicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.