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EC number: 421-320-0 | CAS number: 118289-55-7 CP-89,575
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 and 24 October 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Principles of method if other than guideline:
- The study was conducted in accordance with EEC Methods for Determination of Ecotoxicity Annex to Directive 92/69/EEC (O.J. No. L383A, 29.12.92) Part C, Method 1 "Acute toxicity for Fish" and the OECD Guideline for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test.
Groups of seven juvenile fish were exposed to a range of saturated solutions of CP-89,575 in water, nominally 1.0, 2.2, 4.6, 10, 22, 46 and 100%. Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 3, 6, 24, 48, 72 and 96 hours exposure - GLP compliance:
- yes
Test material
- Reference substance name:
- 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
- EC Number:
- 421-320-0
- EC Name:
- 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
- Cas Number:
- 118289-55-7
- Molecular formula:
- Hill formula: C10 H9 Cl2 N O CAS formula: C10 H9 Cl2 N O
- IUPAC Name:
- 6-chloro-5-(2-chloroethyl)-2,3-dihydro-1H-indol-2-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Expiry: 2 June 1999
Purity: 98.82% by hplc
Date received: 2 June 1997
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
NA
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Test concentrations were verified by chemical analysis. Duplicate medium samples (100 ml) were taken from the control and each test concentration at 0 and 72 hours (fresh media), 24 and 96 hours (expired media) for analysis .
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 2 g of the test substance was added to 20 litres of diluent water in duplicate and stirred overnight using a Stuart Scientific SM8 magnetic stirrer with a I 0 em follower at approximately 250 revs/min. Following stirring the solutions were removed and filtered through a 0.45 J.lm filter. The filtrate was used as the I 00% saturated solution and appropriate volumes of this solution made up to 20 litres gave the further test solutions of I.O, 2.2, 4.6, I 0, 22 and 46% saturated
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Name:Rainbow trout
Source: Parkwood Trout Farm, Kent, UK. obtained from the supplier on 16 July 1997
Temperature: 15 °C
dissolved oxygen : within the range 8.2 to 9.2 mg0/1 in the 14-day period immediately prior to the study
Feeding: fed daily to repletion with commercial fry pellet but food was not given during the 24 hour period immediately before exposure or during the exposure period itself.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- In addition to observations on mortality at 3, 6, 24, 48, 72 and 96 hours, subjective assessments were also made on the type and incidence of sub-lethal effects compared with control fish
Test conditions
- Hardness:
- The water used for the study was laboratory tap water filtered, dechlorinated and softened by passage through an Elga® water purification system.A proportion of the supply then passes through a water softener before final reverse osmosis treatment to produce a highly purified water supply. The two grades of dechlorinated water are then remixed in the ratio of approximately 1 : 1 to give a supply with the desired water hardness
.148 and 164 mgCaC0/1 - Test temperature:
- maintained at 14 °C throughout the exposure period
- pH:
- Between 7.6 and 8
- Dissolved oxygen:
- Between 8.9 and 9.5
- Salinity:
- No data
- Nominal and measured concentrations:
- Mean measured concentrations: 0.025, 0.056, O.II, 0.25, 0.56, 1.2 and 2.5 mg/1
- Details on test conditions:
- Supplementary aeration was provided via narrow bore glass tubes in this study. A photoperiod of 16 h light : 8 h dark was maintained and daily records of temperature.The fish were not fed during the 96 hour exposure period.
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 2.5 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortalities were observed during the exposure period. However, marked reactions to exposure (other than death) were increased pigmentation in the 100% saturated level
- Results with reference substance (positive control):
- NA
- Reported statistics and error estimates:
- No Data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 h LC50 value for CP-89,575 with rainbow trout was >2.5 mg/1, the highest mean measured concentration achieved in this study.
The 'no-observed effect concentration' for CP-89,575 with rainbow trout was 1.2 mg/1.
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