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Diss Factsheets
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EC number: 220-150-2 | CAS number: 2643-07-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Toxicity:
- oral: LD50 = 78.5 mg/kg bw (rat);
- inhalation (IRT): LC50 > 1.68 mg/L air, 7 h (rat);
- dermal: 1630 mg/kg bw (rat);
Key value for chemical safety assessment
Additional information
Oral:
In the key study that was conducted equivalent or similar to OECD TG 401 groups of 5 rats per sex per dose received the test substance by gavage at the dose levels 31.6, 46.4, 68.1, 100, 147, 464, and 2150 mg/kg bw, and were observed for 14 days (BASF AG, 1980). An LD50 of 78.5 mg/kg bw was obtained.
Inhalation:
The acute inhalation toxicity of the test substance was evaluated in an Inhalation Risk Test (IRT) according to Smyth et al. (Am. Ind. Hyg. Ass. J. 23, 95-107, 1962) with 12 rats exposed to an atmosphere enriched with the test substance vapor at a concentration of 1.68 mg/L of air for a period of 7 hours (BASF AG, 1980). No mortality occurred, no signs of toxicity were observed and nothing abnormal was detected during dissection. An LC50 of > 1.68 mg/L/7 h was obtained.
Dermal:
In the key study that was conducted equivalent or similar to OECD TG 402 with the exception that an occlusive coverage was used, groups of 5 rats per sex per dose received the test substance at doses of 200, 400, 1000, 1470, 2000, 2610, 3160, 4640 mg/kg bw, and were observed for 14 days (BASF AG, 1980). An LD50 of 1630 mg/kg bw was obtained in female rats (males: > 4640 mg/kg bw).
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- Toxic if swallowed, R25
- Harmful in contact with skin, R21
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
- Oral route: Acute Category 3
- Dermal route: Acute Category 4
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.