Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-143-3 | CAS number: 78-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72 hour ErC50 (EC50 -growth) for isoprene is >35.2 mg/L and the NOEC is 6.0 mg/L based on growth rate. TLM QSAR modelling was used to calculate EL50 and NOELR of isoprene towards P. subcapitata. The calculated EL50 is 17.761 mg/L and NOELR is 3.403 mg/L.
The lowest value was used for chemical safety assessment.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 17.761 mg/L
- EC10 or NOEC for freshwater algae:
- 3.403 mg/L
Additional information
Huntingdon Life Science (2004) reports 72-hour ErC50 and EbC50 values of >35.2 and 15.3 mg/L respectively, and 72-hour NOEC values based on growth rate and biomass of 6 and 1.68 mg/L respectively, for the freshwater Pseudokirchneriella subcapitata in a standard OECD TG 201 test. This result was from a static study with analytical confirmation of the exposure concentrations. The result is based on the mean of measured exposure concentrations.
For acute toxicity to algae, the key study gives a 72 hour EC50 of 35.2 mg/L (HLS 2004) and additional data are available from regulatory documents and QSARs for isoprene, give results ranging from 9.4 to >1000 mg/L. The key study has been chosen as it an experimental result from a reliable study while the additional data are taken from study summaries or computer estimations.
For chronic toxicity to algae, a key study is available giving a 72 hour NOEC of 6 mg/L (HLS 2004). Additional data are available from regulatory documents and QSARs for isoprene, with results ranging from a ChV of 1.83 mg/L (which when divided by v2 to adjust for ChV being a geometric mean of NOEC and LOEC, corresponds to a NOEC of 1.29 mg/L) to a NOEC of 83 mg/L. The key study has been chosen as it an experimental result from a reliable study while the additional data are taken from study summaries or computer estimations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.