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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 207-866-0 | CAS number: 498-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 9 577 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 26 590 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 353 mg/kg bw
Additional information
Oral Toxicity
The acute oral toxicity of Norbornene was determined in groups of 5 male Carworth-Wistar rats, each receiving an oral dose of the test substance by gavage. Dosage range was spaced in a logarithmic spacing of a factor 2. The observation period was 14d. The LD50 was determined with a range of +/-1.96 standard deviations according to the calculation method of Thomson (1947). Overall the study was conducted similar to OECD 401 (retracted). The acute oral LD50 was 9577 mg/kg b.w. in male rats (Smyth, 1969)
Dermal Toxicity
the acute dermal toxicity was determined in groups of 4 male albino New Zealand rabbits, each receiving a graduate single dose of test substance followed by 24h occlusive wrapping and 14 d observation. From mortality data the LD50 was calculated as > 5 ml/kg corresponding to > 4353 mg/kg. (Smyth, 1969)
Inhalative toxicity
In an acute inhalation toxicity study, norbonene was applied as an aerosol at 26.59 mg/l air to groups of 5 young adult male and female Wistar rats in an nose only type of experiment. The animals observed for 14d. Clinical symptons were reversible within two days. Two male rats dies shortly after exposure. The combined LC50 > 26.59 mg/l air. (Hofmann, 1995)
Justification for classification or non-classification
in dermal and inhalative acute toxicity testing the dose range did not suffice to determine LD50 values. The observed values are LD50: oral 9577 mg/kg; dermal > 4353 mg/kg, inhalative >26.59 mg/l (aerosol)
Based on these values, no classification according to EU criteria is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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