Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
Substance specific data on effects on fertility is not required for substances registered as transported isolated intermediate >1000 t/a according to Annex VII of REACH regulation. Since the registered substance Alkaline co-precipitation products of soluble cobalt, manganese and nickel salts and the different constituents of the UVCB release the same toxicological relevant unit under physiological relevant conditions, the overall toxicity of dissolved nickel, cobalt and manganese ions can be used to assess the toxicity of the registered substance for endpoints where substance specific data is not required. Therefore, data from Nickel dihydroxide, Cobalt dihydroxide, Tricobalt tetraoxide, Trimanganese tetraoxide and Manganese dioxide are used for hazard assessment based on a worst-case mixture approach.
Cobalt dihydroxide is classified for reproductive toxicity as Repro. 1B (H360F) under Regulation (EC) No. 1272/2008.
Based on the available data Nickel dihydroxide, Tricobalt tetraoxide, Trimanganese tetraoxide and Manganese dioxide are not classified for effects on fertility under Regulation (EC) No. 1272/2008.
Effects on developmental toxicity
Description of key information
Substance specific data on effects on developmental toxicity is not required for substances registered as transported isolated intermediate >1000 t/a according to Annex VII of REACH regulation. Since the registered substance Alkaline co-precipitation products of soluble cobalt, manganese and nickel salts and the different constituents of the UVCB release the same toxicological relevant unit under physiological relevant conditions, the overall toxicity of dissolved nickel, cobalt and manganese ions can be used to assess the toxicity of the registered substance for endpoints where substance specific data is not required. Therefore, data from Nickel dihydroxide, Cobalt dihydroxide, Tricobalt tetraoxide, Trimanganese tetraoxide and Manganese dioxide are used for hazard assessment based on a worst-case mixture approach.
Nickel dihydroxide is classified for developmental toxicity as Repro. 1B (H360D) under the 1st ATP to the CLP. Cobalt dihydroxide and Trimanganese tetraoxide are classified for developmental toxicity as Repro. 2B (H361d) under Regulation (EC) No. 1272/2008. Based on the available data Tricobalt tetraoxide and Manganese dioxide are not classified for developmental toxicity under Regulation (EC) No. 1272/2008.
Justification for classification or non-classification
Based on the mixture approach, the registered substance is classified for toxicity to reproduction as Repro. 1B (H360FD) under Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
