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Diss Factsheets
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EC number: 293-766-2 | CAS number: 91082-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- This in vivo study was performed, before the amendments to the data requirements in Annex VII and VIII came into force.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- - Principle of test: A single rabbit was used in an initial assessment of the skin irritation potential of the test substance. The neat substance was applied to the shorn skin of the rabbit under a semi-occlusive dressing for 3 minutes or one hour.
- Short description of test conditions: The animal was exposed via the skin to ca. 0.5 mL of the neat substance applied to each of 2.5 cm square areas on the left flank of the shorn dorso-lumbar region under a semi-occlusive dressing for 3 minutes or one hour. On removal of the dressings, the skin was cleansed with clean, warm water.
- Parameters analysed / observed: The application sites were assessed for erythema and oedema, using the Draize scale, immediately after the removal of the dressings and at one hour after removal of the dressings for the three minute application. - GLP compliance:
- no
Test material
- Reference substance name:
- Tar bases, coal, lutidine fraction
- EC Number:
- 293-766-2
- EC Name:
- Tar bases, coal, lutidine fraction
- Cas Number:
- 91082-52-9
- IUPAC Name:
- Tar bases, coal, lutidine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: not reported
- Weight at study initiation: 3236 g
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reporte
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 3 minutes and 1 hour
- Observation period:
- Not applicable
- Number of animals:
- One animal was used in the initial study. Due to the severity of the responses seen, the animal was terminated after one hour following the initial application and no further animals were dosed.
- Details on study design:
- TEST SITE
- Area of exposure: ca. 2.5 cm square
- % coverage: not reported
- Type of wrap if used: not reported
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin was cleansed with clean warm water
- Time after start of exposure: one hour
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): immediately after cleansing of the skin
SCORING SYSTEM:
- Method of calculation: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 3 minutes
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not tested
- Remarks:
- Animal was sacrificed after 1 hour due to severity of effects
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 3 minutes
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- other: not tested
- Remarks:
- Animal was sacrificed after 1 hour due to severity of effects.
- Irritant / corrosive response data:
- Following a single three-minute application of the test substance, well defined erythema was seen up to one hour after application. Severe oedema was also seen one hour after application. Severe erythema and severe oedema were seen immediately after decontamination following a single one-hour application. Large areas of black necrosis were also seen on the application site.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- The substance was corrosive to the skin of a rabbit treated with a single dermal dose of the neat substance for 1 hour.
- Executive summary:
The skin irritation/corrosion potential of the substance was studied in this in vivo study under non GLP following the principle of the OECD regulatory guideline. The experiment is considered relevant, adequate and conclusive.
One male New Zealand White albino rabbit, weighing 3236 g, was used for an initial assessment of the irritation potential. Approximately 0.5 mL of the neat test substance was applied to each of two 2.5 cm square areas on the left flank of the shorn dorso-lumbar region under a semi-occlusive dressing for three minutes or one hour. On removal of the dressing, the skin was cleansed with clean warm water. The application sites were assessed for erythema and oedema, using the Draize scale, immediately after the removal of the dressings and at one hour after the removal of the dressing for the 3-minutes application. Any other signs of skin irritation were also noted. Following a single three-minute application of the test substance well-defined erythema was seen up to one hour after application. Severe oedema was also seen one hour after application. Severe erythema and severe oedema were seen immediately after cleansing of the application following a single one-hour application. Large areas of black necrosis were also seen on the application site. Due to the severity of the responses seen, the animal was sacrificed after one hour following the initial application and no further animals were dosed.
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