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EC number: 293-766-2 | CAS number: 91082-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- - Principle of test: Groups of five male and five female rats received a single dermal dose of the test substance. The animals were then observed daily for a period of 14 days.
- Short description of test conditions: Animals received a single dermal dose of the test substance of 0.05, 0.15, 0.25 and 0.4 mL/kg. The undiluted test substance was applied to the shorn back of each animal and was kept in contact with the skin for 24 hours under occlusive dressing. At the end of the exposure period, the dressings were removed.
- Parameters analysed / observed: Animals were checked regularly for mortality and any sign of toxicity. At the end of the study, surviving animals were humanely killed and were examined by necropsy for any macroscopic abnormalities. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tar bases, coal, lutidine fraction
- EC Number:
- 293-766-2
- EC Name:
- Tar bases, coal, lutidine fraction
- Cas Number:
- 91082-52-9
- IUPAC Name:
- Tar bases, coal, lutidine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: colony maintained in the laboratory at Alderley Park, Cheshire, UK
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: not reported
- Weight at study initiation: bodyweight range 164-278 g for females and 230-288 g for males
- Fasting period before study: not reported
- Housing: not reported
- Diet (e.g. ad libitum): not reported
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: not reported
- Type of wrap if used: not reported
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): appropriate volumes of the test substance were applied to achieve the envisaged dermal doses - Duration of exposure:
- 24 hours
- Doses:
- 0.05, 0.15, 0.25 and 0.4 mL/kg (dose levels were converted to mg/kg by applying a factor of 1000).
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights - Statistics:
- The acute dermal median lethal dose was calculated from the mortality data using logistic regression. Confidence limits were calculated using a likelihood ratio interval (Williams 1986).
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 236 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 190 - 293
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 316 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 250 - 400
- Mortality:
- None of the animals died following a single dermal dose of 0.05 or 0.15 mL/kg. Three out of five females dosed at 0.25 mL/kg and all ten animals dosed at 0.4 mL/kg died or were killed in extremis.
- Clinical signs:
- other: No significant signs of toxicity were seen in the animals dosed at 0.05 or 0.15 mL/kg. Moderate irritation effects were seen in some of these animals and persisted for most of the study. Slight signs of toxicity were seen for the first few days in the mal
- Gross pathology:
- No macroscopic abnormalities were detected during necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The test substance was found to be acutely toxic to rats when applied as a single dose of undiluted material to the shorn skin and kept under occlusion for 24 hours.
- Executive summary:
The acute dermal toxicity of the test substance was investigated under non-GLP in a study similar to an OECD guideline study. The experiment is considered relevant, adequate and conclusive.
Groups of five female and five male Alderley Park SPF albino rats, in the bodyweight range from 164-278 g for females and 230-288 g for males, were used for each dose. Single doses of 0.05, 0.15, 0.25 and 0.4 mL/kg (corresponding to 50, 150, 250 and 400 mg/kg) of undiluted substance were applied to the shorn skin on the back of test animals on Day 1. The animals were observed daily up to Day 15. None of the animals receiving a single dose of 0.05 and 0.15 mL/kg died. Three female animals dosed at 0.25 mL/kg died on Day 1. All animals dosed at 0.4 mL/kg died on Day 1. No significant signs of toxicity were seen at the two lowest doses, but moderate skin irritation was observed that persisted for most of the study. Slight signs of toxicity were seen in males dosed at 0.25 mL/kg for the first four days after exposure, and severe skin irritation occurred that persisted for most of the study. Marked signs of toxicity were seen in the surviving females dosed at 0.25 mL/kg, and slight irritation was also seen in these animals. Signs of toxicity including mydriasis, prostration and breathing abnormalities were seen in animals of the top dose group. All surviving animals gained weight throughout the study. No macroscopic abnormalities were detected at necropsy.
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