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EC number: 256-289-0 | CAS number: 46948-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-08-27 to 1984-09-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according the OECD Guideline 203 with no deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 6-[methyl(phenylsulphonyl)amino]hexanoic acid
- EC Number:
- 256-289-0
- EC Name:
- 6-[methyl(phenylsulphonyl)amino]hexanoic acid
- Cas Number:
- 46948-72-5
- Molecular formula:
- C13H19NO4S
- IUPAC Name:
- 6-(N-methylbenzenesulfonamido)hexanoic acid
- Details on test material:
- n.a.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n.a.
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- n.a.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test was separated two allow a fine tuning of the test concentrations (all nominal). Part 1: 0 and 500 mg/L, Part 2: 0, 10 and 100 mg/L, Part 3: 0, 177, 250 and 354 mg/L. Reconstituted water. Solid test substance was dispersed in the test water with Ultra-Turrax (highest speed) and afterwards stired for 2 hours. Test concentrations 10 to 354 mg/L were visually clear. At 500 mg/L solids at the bottom of the test container was observed.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Own breeding at Hoechst laboratory, hatched 1984-06-13 respectively 1984-06-06. Length of fish 3.2 cm (mean). 10 fish per test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96
- Remarks on exposure duration:
- h
- Post exposure observation period:
- n.a.
Test conditions
- Test temperature:
- 22° C +/- 1
- pH:
- 7.9-8.1
- Dissolved oxygen:
- 80% saturation
- Salinity:
- n.a.
- Nominal and measured concentrations:
- nominal concentration
- Details on test conditions:
- O2: 80% saturation, 12h light period, fish density < 1 g fish/L, feed: 2 per day ad libitum (Tetra min fish feed). Fish were visually inspected after 2, 4, 24, 48, 72 and 96h.
- Reference substance (positive control):
- not required
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 177 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 210 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: The LC50 value was derived as geometric mean of LC0 (96h) and LC100 (96h) being adjacent concentrations as no statistical evaluation was possible.
- Details on results:
- Mortality rates were recorded after 48 and 96h.
- Results with reference substance (positive control):
- n.a.
- Reported statistics and error estimates:
- A statistical evaluation was not possible as the LC0 and LC100 were adjacent concentrations. Instead the geometric mean of LC0 and LC100 was used to derive the LC50.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The registration substance was tested in an acute fish test according OECD Guideline 203. The LC50 (96h) of 210 mg/L was derived as geometric mean of the two adjacent concentrations reflecting the LC0 (96h) of 177 mg/l and the LC100 (96h) of 250 mg/L).
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