Registration Dossier
Registration Dossier
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EC number: 256-289-0 | CAS number: 46948-72-5
Mode of degradation in actual use
Administrative data
- Endpoint:
- mode of degradation in actual use
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-10-24 to 2005-11-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Analytically verified non-Guideline investigation on metabolismn, no deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigation of the metabolites formed during a test on inherent biodegradability (OECD 302B Zahn-Wellens/EMPA Test) using GC.
- GLP compliance:
- no
- Remarks:
- no Guideline available for GLP setting
Test material
- Reference substance name:
- Hexanoic acid, 6-[methyl(phenylsulfonyl)amino]-
- IUPAC Name:
- Hexanoic acid, 6-[methyl(phenylsulfonyl)amino]-
- Details on test material:
- see IUCLID Section 5.2.1 on details
Constituent 1
Results and discussion
Any other information on results incl. tables
Hexanoic acid, 6-[methyl(phenylsulfonyl)amino]- (Ph-SO2-N(CH3)(CH2)nCOOH, n=5) is oxidatively degraded along the carbon chain of the hexanoic acid part of the substance. During the 28d test metabolites with n=3, 2 and 1 could be identified by GC. At day 28 the metabolite with n=1 was the predominate one. One metabolite could not be analytically verified but it may be the N-Methylphenylsulfonamide.
Applicant's summary and conclusion
- Executive summary:
Based on the analytical investigations during an inherent biodegradation test according OECD 302B it could be verified that the registration substance is primarily biodegraded forming as major metabolite Ph-SO2-N(CH3)(CH2)nCOOH with n=1 (N-(Phenylsulfonyl)sarcosine (SPS), CAS No. 46376 -16 -3). The degradation half-life of this major metabolite is not known. These findings are supported by scientific investigations on substances being relevant for the purification of drinking water from surface waters (Lindner, K. et al, IARW/VCI Scientific Investigation, Determination and Assessment of the microbial degaradation of chemical substances with relevant environmental concentrations, Final report 2003, ISBN 90 -70671 -32 -8, http://www.iawr.org/docs/fachberichte/rt5.pdf). Measured concentration of the metabolite SPS in Germans surface waters were published in 2001 (Werres, F et al, Occurence of industrial chemicals in surface waters, Acta Hydrochimica et Hydrobiologica (2001), 29(1), 16 -21).
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