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EC number: 435-410-2 | CAS number: 351491-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 02 May 2000 to 23 August 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.48
- Temp.:
- 23 °C
- pH:
- 6
- Type:
- log Pow
- Partition coefficient:
- > 2.53 - < 2.54
- Temp.:
- 23 °C
- pH:
- 6
- Remarks on result:
- other: ratio of stock solution:water (1:10)
- Type:
- log Pow
- Partition coefficient:
- > 2.36 - < 2.4
- Temp.:
- 23 °C
- pH:
- 6
- Remarks on result:
- other: ratio of stock solution: n-octanol: water (1:1:20)
- Type:
- log Pow
- Partition coefficient:
- > 2.5 - < 2.51
- Temp.:
- 23 °C
- pH:
- 6
- Remarks on result:
- other: ratio of stock solution: water (4:15)
- Conclusions:
- The log Kow of the test item is 2.48 at pH 6 and 23°C. Based on this value, the test item is considered to not possess a potential for bioaccumulation.
- Executive summary:
The partition coefficient of the test item was determined with the flash method according to recognised guideline and under GLP. No deviation from the guideline was observed during the test.
The test item partition coefficient was estimated in a preliminary test. Then a main test was performed using three vessels with different ratios of n-octanol and aqueous phase.
The log Kow of the test item is 2.48 at pH 6 and 23°C. Based on this value, the test item is considered to not possess a potential for bioaccumulation.
Reference
The value of the partition coefficient was estimated from the solubilities of the test substance in the pure solvents.
For the solubility of the test substance in water, the value obtained in the water solubility was used (355.7 mg/l). For the solubility of the test substance in n-octanol, the test substance was mixed with n-octanol in proportion of 1:1, respectively 1:2 and 2:1. The test substance totally mixed with n-octanol in all proportions. Therefore, a solubility of 1 000g/l n-octanol was established.
The log of the estimate of the partition coefficient n-octanol/water was calculated was 3.4.
In the main test, the test item recoveries in n-octanol and aqueous phases were determined. The recoveries were between 104 and 106%.
Description of key information
The partition coefficient of the test item was determined in an experimental key study of Klimisch validity 1.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.48
- at the temperature of:
- 23 °C
Additional information
Based on its log partition coefficient, the test item is considered to not possess a potential for bioaccumulation.
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