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EC number: 460-280-9 | CAS number: 302964-24-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Inhalation: Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get medical attention/advice
Eyes: Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while
rinsing. Obtain medical attention.
Skin:If ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs, seek
medical advice/attention. Wash contaminated clothing before re-use.
Ingestion: IF SWALLOWED: Immediately call a POISON CENTRE or doctor/physician. Rinse
mouth.
Fire-fighting measures
Recommended extinguishing agent: Dry foam, powder and water spray. Do not use water jet. Product arising from burning: Complete combustion will lead to the formation of oxides of
carbon, nitrogen and sulphur. Reduced forms of these oxides
(eg. carbon monoxide) may result from combustion in enclosed spaces. Other possible combustion products
following incomplete oxidation may include gaseous hydrogen chloride. Protective equipment: Full protective equipment including self-contained breathing
apparatus, suitable gloves, goggles and face protection must
be worn.
Further Information: HCl gas can form flammable or explosive mixtures with alcohols or
metals. In the event of fire and/or explosion do not breathe fumes.
Decontaminate protective clothing and equipment before reuse. Avoid generating dust;
fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition
source is a potential dust explosion hazard.
Accidental release measures
Emergency measures in case of spillage: The affected area will be fenced or cordoned off and individuals will not be allowed to touch or walk through the spilled material unless wearing appropriate protective clothing. Dust generation will be avoided. Suitable protective clothing will include gloves and eye/face protection. As a minimum this will include: tightly fitting safety goggles,, disposable lab coat of low permeability with cuffs,
double gloves, shoe covers, and an approved respirator. Depending upon the nature of the spill (quantity and extent of spill), additional protective clothing and equipment such as self-contained breathing apparatus may be needed. Any dusts will be moistened to prevent generation of aerosols and covered with suitable material. The substance will be placed in a suitable properly labelled container for disposal according to local regulations.
Cleanup Methods Contain and collect spillage and place in container for disposal according to local
regulations (see Section 13). Use a HEPA vacuum or moisten materials to minimize dust
generation during pick-up. Clean area with detergent and water after spill pick-up, if
appropriate. Handle waste materials, including gloves, protective clothing, contaminated
spill cleanup material, etc., as appropriate for chemically and pharmacologically similar
material
Handling and storage
Handling Precautions Avoid exposure - obtain special instructions before use. Avoid formation of dust and
aerosols. Keep away from heat and sources of ignition. Prevent release to drains and
waterways. Use of inert gas should be considered to minimize the risk of ignition.
Minimize dust generation and accumulation. Routine housekeeping should be instituted to
ensure that dusts do not accumulate on surfaces. Dry powders can build static electricity
charges when subjected to the friction of transfer and mixing operations. Provide adequate
precautions, such as electrical grounding and bonding, or inert atmospheres.
Container Requirements: Store in sturdy containers appropriate to maintain the integrity of this material for its
Storage Conditions Store at room temperature. 15 - 30°C Protect against light. Keep away from heat, sparks
and flames. Store locked up.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- UN2811
Shipping information
- Proper shipping name and description:
- Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)
- Chemical name:
- Thiazolecarboxamide Derivative
- Language:
- English
- Labels:
- 6.1
SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- UN2811
Shipping information
- Proper shipping name and description:
- Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)
- Chemical name:
- Thiazolecarboxamide Derivative
- Language:
- English
- Labels:
- 6.1
Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- UN2811
Shipping information
- Proper shipping name and description:
- Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)
- Chemical name:
- Thiazolecarboxamide Derivative
- Labels:
- 6.1
Remarksopen allclose all
Air transport (UN RTDG/ICAO/IATA)
- UN number:
- UN2811
Shipping information
- Proper shipping name and description:
- Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)
- Chemical name:
- Thiazolecarboxamide Derivative
- Labels:
- 6.1
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Engineering Controls and Ventilation
Use process enclosures, containment technology, or other engineering controls to keep
airborne levels below recommended exposure limit. When handling quantities up to 15
milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air
changes per hour) is appropriate. When handling quantities from 15 milligrams to 1 kilogram,
work in a standard laboratory using a fume hood, biological safety cabinet(Class II, all types),
or approved vented enclosure. Quantities exceeding 1 kilogram should be handled in a
designated laboratory. A laminar flow/powder containment booth is recommended for
handling >1 kilograms of active substance. For manufacturing and pilot plant operations, use
direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as
appropriate. HEPA filtration of local exhaust ventilation (LEV) is required. It is
recommended that all dust control equipment such as local exhaust ventilation and material
transport systems involved in handling of this product contain explosion relief vents or an
explosion suppression system or an oxygen deficient environment. Ensure that dust-handling
systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are
designed in an manner to prevent the escape of dust into the work area (i.e., there is no leakage
from the equipment). Use only appropriately classified electrical equipment and powered
industrial trucks.
Respiratory protection
Use and selection of respiratory protection is based upon engineering controls in use and
potential for aerosol generation. When engineering controls are not sufficient control
exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate
(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure
control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying
respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control
guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters
(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,
full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure
control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied
air respirator (EN 139) operated in a pressure demand or other positive pressure mode when
exposures are 100-1000 times the exposure control guideline.
Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety
goggles (EN 166) may be required if splash potential exists or if corrosive materials are
present. Note: Choice of eye protection may be influenced by the type of respirator which is
selected.
Hand protection Impervious nitrile, rubber and latex gloves are recommended. If material is handled in
solution, the solvent should also be considered when selecting protective clothing material.
Please note that employees who are allergic to natural rubber latex should use nitrile gloves.
Skin and body protection
Wear a laboratory coat when handling quantities up to 1 kilogram. For quantities over 1
kilogram, wear laboratory coat or coverall of low permeability. For manufacturing operations,
wear coverall of low permeability.
Wear a laboratory coat when handling quantities up to 1 kilogram. For quantities over 1
kilogram, wear laboratory coat or coverall of low permeability. For manufacturing operations,
wear coverall of low permeability.
Hygiene Wash hands and face before breaks and immediately after handling the product.
Stability and reactivity
Danger other than fire: None known. Stable under normal conditions
Chemical reaction with water: There is not considered to be any adverse reaction with wate
r.
Dust explosion: The material exhibits strong explosion
characteristics if ignited as a dust cloud (Kst 236
bar.m/sec).
The material is very susceptible to igniting as a dust cloud
under certain conditions due to low minimum ignition energy
(>10 - <25 mJ).
The material has low sensitivity to accumulating static
charges during processing (8.2E+13 ohm.m).
Charge decay time (ambient) 33 minutes
Ignition temperature >600°C
Powder handling equipment such as dust collectors, dryers
and mills may require additional protective measures (e.g.
explosion venting, inerting, etc.). Suitable bonding and
grounding containers and process equipment to control static
discharges and to control accumulation of static charges
will be provided. Use of inert gas will be considered to
minimize the risk of ignition.
Dust explosion determined by test: Y
Disposal considerations
Industry - Possibility of recovery/recycling: Discharge to the environment will be minimal. Trace quantities are destroyed by biological oxidation in the on- site and local municipal wastewater treatment plants. Recovery of larger spillages of uncontaminated material for subsequent use is recommended. As material is used in the process, no recycling of material is possible. Industry - Possibility of neutralisation: No method of neutralisation is known. Industry - Possibility of destruction: controlled discharge: Trace quantities are destroyed by biological oxidation in wastewater treatment plants. Industry - Possibility of destruction - incineration: Incineration is used as standard system for treating mother liquors. A closed-cycle incinerator with scrubbers should be employed. National and local regulations must be observed. Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to the sewage system or aqueous environment. However, there are unlikely to be adverse effects on sewage treatment systems, because the substance has been shown not to be unduly toxic to sewage microorganisms. Industry - Possibility of destruction - other: None known
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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