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EC number: 801-277-8 | CAS number: 507448-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- yes
Test material
- Reference substance name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
- EC Number:
- 801-277-8
- Cas Number:
- 507448-65-9
- Molecular formula:
- C7H10F3NO2
- IUPAC Name:
- ethyl (2Z)-4,4,4-trifluoro-3-(methylamino)but-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd. Biotechnology & Animal Breeding Division. CH-4414 Füllinsdorf / Switzerland
- Age at study initiation: Young adult (approximately 8 - 12 weeks)
- Weight at study initiation: 210 - 268 g
- Housing: Individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C ± 3 °C
- Humidity (%): 50 % ± 20 %
- Air changes (per hr): 13 - 14
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6 cm x 6 cm
- % coverage: 10 %
- Type of wrap if used: Test item applied evenly to whole shaved area by means of a gauze-lined semiocclusive dressing fastened
around the trunk with an adhesive elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: The skin was cleaned with lukewarm water.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount applied: 200 mg per 100 g body weight.
- Concentration: 100 % (undiluted) - Duration of exposure:
- 24 hours
- Doses:
- One single dose, 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Period of observation: 14 days after end of treatment
- Clinical observations: Checked and recorded individually within the first two hours then daily for the duration of the observation
period.
- Local tolerance: The application site was examined daily for signs of dermal irritation. Any deviations from normal were recorded using the Draize scale
- Mortality: Checked twice daily, morning and afternoon.
- Body weight: Measured and recorded immediately before dose administration, on days 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - Mortality: There was no mortality in the study.
- Clinical signs:
- other: - Clinical observations: There were no remarkable clinical observations for any animal.
- Gross pathology:
- - Necropsy: Necropsy examinations revealed no observable abnormalities.
- Other findings:
- - Local tolerance: There were no remarkable findings at the application site.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The following acute oral LD50 values were determined for CA 2455 A Intermediate of CGA 276854):
LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Executive summary:
Groups of 5 male and 5 female rats were administered a single dose of CA 2455 A (Intermediate CGA 276854) (batch lot 3) by dermal application at a dose levels of 2000 mg/kg for 24 hours under semiocclusive conditions, followed by a 14 day post-treatment observation period.
There was no mortality in the study.
There were no remarkable clinical observations nor were there any remarkable findings at the application site for any animal.
A slight loss of body weight was recorded in two females during the second week after treatment.
Body weights were not affected by the treatment.
Necropsy examinations revealed no observable abnormalities.
The following acute oral LD50 values were determined for CA 2455 A Intermediate of CGA 276854):
LD50in male rats: Greater than 2000 mg/kg body weight
LD50in female rats: Greater than 2000 mg/kg body weight
LD50in rats of both sexes: Greater than 2000 mg/kg body weight
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