Registration Dossier
Registration Dossier
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EC number: 606-738-5 | CAS number: 213265-81-7
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
- Cas Number:
- 213265-81-7
- Molecular formula:
- C10H5Cl2FN2O
- IUPAC Name:
- 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 13 900 h
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- other: Within five days the degradation was less than 10%.
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- other: Within five days the degradation was less than 10%.
Any other information on results incl. tables
The calculation of the half times and the reaction rate constants were based on linear regression (In c versus t and In k versus T"1 respectively) following the first order concentration-time-law.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance is hydrolytically not degradable at pH 7 and pH 4.
The test substance is hydrolytically degradable at pH 9.
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