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EC number: 238-063-3 | CAS number: 14206-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The free acid was tested for acute oral toxicity in OECD guideline conform studies (OECD SISDS SIAM 19). The substance caused gastro-intestinal irritation and mottled liver, and mortalities occured within 35 min - 1 day after administration. LD50 was calculated to be 823 mg/kg bw/day. An acute dermal toxicity study was also performed but poorly documented and not sufficient for a statement on classification.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 823 mg/kg bw
Additional information
Reasons for read across
The test item is the sodium salt of a naphthoic acid. In an acidic enviroment (e.g. stomach), the salt complex becomes dissociated into the sodium cation and the organic acid. Therefore, it is acceptable to derive acute toxicity data from the free acid.
Assessment acute toxicity according OECD SIDS (SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid)
The free acid was tested for its acute oral toxicity in two studies performed in accordance with OECD TG 401. In these studies, an oral LD50 in the range between 823 and 1040 mg/kg bw was determined in rats of both sexes. Clinical signs included reduced activity, accelerated breathing, closure of eyes, and diarrhoea. All deaths occurred between 35 minutes and one day after exposure. Gastro-intestinal irritation and dark or mottled livers were seen in the animals that had died during the study, whilst the surviving animals were free of pathological changes at the end of the 14-day observation period LD50 values in the range between 800 and 2450 mg/kg bw have been reported for the rat in other, poorly documented and limited studies and publications.
In a poorly documented, old and very limited study, a dose of 2000 mg/kg bw applied dermally caused the death of a guinea pig, whilst 1000 mg/kg bw were non-lethal (Eastman Kodak, 1954). In this study, only one animal was used per dose level, and the exposure was for 24 hours under occlusive conditions. At the highest dose level (approximately 2000 mg/kg bw; applied as a 10% solution in acetone:corn oil) necroses were seen which covered about one half of the total application area.
Conclusion
The acute oral LD50 in rat was between 823-1040 mg/kg bw. Clinical signs included reduced activity, accelerated breathing, closure of eyes, and diarrhea. Gastro-intestinal irritation and dark or mottled livers were seen in the animals that had died during the studies.
A poorly documented study showed that 10% solution of 3-hydroxy-2-naphthoic acid (approx. 2000 mg/kg bw) was lethal to guinea pigs when applied dermally for 24 hours under occlusive conditions.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available oral studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is considered to be classified for acute oral toxicity under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data on oral toxicity are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance is considered to be classified for acute oral toxicity under Regulation (EC) No. 1272/2008.
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