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EC number: 683-287-0 | CAS number: 877670-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II) (January 2012)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-(2-{1-[(2-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl)benzoic acid
- EC Number:
- 683-287-0
- Cas Number:
- 877670-90-1
- Molecular formula:
- C18H17N3O5
- IUPAC Name:
- 2-(2-{1-[(2-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl)benzoic acid
Constituent 1
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- semi-static
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23.8-24-6°C
- pH:
- 7.02-7.36 (start) 7.32-8.41 (end)
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.58 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: 2.21-3.00
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11.87 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 7.24-19.48
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.52 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Yield
- Remarks on result:
- other: 2.11-3.00
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.35 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth rate and Yield
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.81 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Biomass, Growth rate and Yield
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In this 72-h algal growth inhibition test on Pseudokirchneriella subcapitata with
ANTHRANILIC ACID-AAOA, the 72-h EC50 based on growth rate was
determined as 11.87 mg/L. This EC50 value is higher than the solubility of the test
item in the test media. Yield was the most sensitive parameter with an 72-h EC50
of 2.52 mg/L. The overall NOEC was determined to be 1.35 mg/L. The test item
solutions were slightly coloured and there was a minor absorption at one of the
chlorophyll wavelengths, this could have influenced the growth inhibition,
however the EC50 was above the maximum solubility of the test item. - Executive summary:
The effect of ANTHRANILIC ACID-AAOA test item was assessed on algal growth
using the unicellular green alga Pseudokirchneriella subcapitata (Selenastrum
capricornutum), over an exposure period of 72 hours.
The following concentrations were used in the main study (S.S.=Stock Solution):
S.S./16; S.S./8; S.S./4; S.S./2 and S.S./1. The corresponding measured mean test item
concentrations were: 0.31; 0.62; 1.35; 2.81 and 6.03 mg/L.
The test design included three replicates at each test concentration and six replicates
for the untreated control. At the start of the study the alga cell number was 104 cells/mL in
all of the test cultures.
The observed inhibitions in the definitive test could have been related to the coloured test
material and light absorption, therefore the following additional measurements were
preformed:
The test solutions were formulated again by the same method as during the definitive
test. Thereafter the light absorptions of these test solutions were measured
photometrically. The light adsorption measurements were performed in the range of
350-700 nm, because the absorption maximum of the Chlorophyll A is about 430 and
660 nm and the absorption maximum of Chlorophyll B is about 450 and 640 nm.
The maximum light adsorption of the test item was at ~380 nm in the test solutions.
There was no significant absorption at 450 to 660 nm, but there was some adsorption
at 430 nm.
The light intensity (8127 lux) was in the acceptable range during the definitive test.
In this 72-h algal growth inhibition test on Pseudokirchneriella subcapitata with
ANTHRANILIC ACID-AAOA, the 72-h EC50 based on growth rate was
determined as 11.87 mg/L. This EC50 value is higher than the solubility of the test
item in the test media. Yield was the most sensitive parameter with an 72-h EC50
of 2.52 mg/L. The overall NOEC was determined to be 1.35 mg/L. The test item
solutions were slightly coloured and there was a minor absorption at one of the
chlorophyll wavelengths, this could have influenced the growth inhibition,
however the EC50 was above the maximum solubility of the test item.
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