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EC number: 273-761-1 | CAS number: 69012-64-2 Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A scientific review by authorative international body
- Principles of method if other than guideline:
- OECD evaluated the available test data on synthetic amorphous silica.
- GLP compliance:
- no
- Remarks:
- review - both yes and no status
- Test type:
- other: different acute oral toxicity tests
- Species:
- other: rat and mouse
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 110 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: several silica types
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 20 000 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Remarks on result:
- other: hydrophilic pyrogenic silica
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- OECD (2004) includes 12 acute oral toxicity studies with synthetic amorphous silica, of which five is regarded as critical study for SIDS endpoint. These five studies are conducted with hydrophilic precipitated or pyrogenic silica. In the critical studies, the LD50 or LDO value was at least >3160 mg/kg bw, thus showing no acute oral toxicity.
- Executive summary:
In OECD (2004), the acute oral administration of hydrophilic precipitated or pyrogenic silica either by gavage or in the diet
failed to produce signs of toxicity or deaths in treated animals with LD50values greater than the top doses applied. Thus, the LD50values varied from >3100 to >20000 mg/kg bw. In conclusion, acute oral ingestion to high doses of synthetic amorphous silica will produce no systemic toxicity.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A scientific review by authorative international body
- Principles of method if other than guideline:
- OECD evaluated the available test data on synthetic amorphous silica.
- GLP compliance:
- no
- Remarks:
- 'yes' status in critical studies
- Test type:
- other: different acute inhalation toxicity tests
- Species:
- rat
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 0.139 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: hydrophilic pyrogenic silica
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 0.691 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.08 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: hydrophilic pyrogenic silica
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- OECD (2004) includes seven acute inhalation toxicity studies with synthetic amorphous silica, of which three is regarded as critical study for SIDS endpoint. These three studies are conducted with hydrophilic pyrogenic or precipitated silica. In a study where LC50 > 2.08 mg/L was suggested, none of the animals died. The SAS dusts are considered as acutely non-toxic.
- Executive summary:
OECD (2004) reviewed that there was no lethal effects following inhalation exposure of rats to the highest technically feasible concentrations of 140 to 2000 mg/m3of hydrophilic precipitated or pyrogenic silica. However, the acute inhalation of synthetic amorphous silica dust may cause discomfort and stress as well as sign of local irritation to nasal, bronchiolar and ocular mucous membranes. In conclusion, the synthetic amorphous silica dusts are considered acutely non-toxic via inhalation route.
Reference
All acute inhalation studies performed with dry dust were hampered by the technical problem to achieve the recommended highest test concentration of 5 mg/l, apparently attributable to the high adhesive forces which caused rapid precipitation onto equipment walls. Therefore, the maximum attainable chamber concentrations were distinctly lower than envisaged.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 140 mg/m³ air
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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