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EC number: 800-182-9 | CAS number: 1426148-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-Across of experimental data from analogius compounds based on expert judgement.
Data source
Reference
- Reference Type:
- publication
- Title:
- HERA report on alcohol ethoxylates
- Author:
- A.I.S.E. / CEFIC
- Year:
- 2 009
- Bibliographic source:
- http://www.heraproject.com/RiskAssessment.cfm?SUBID=34
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Investigation of absorption, distribution, metabolism and excretion of alcohol ethoxylates
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethoxylated alcohols (C12 with 3 or 6 EO)
- IUPAC Name:
- Ethoxylated alcohols (C12 with 3 or 6 EO)
- Test material form:
- other: paste, liquid (depending on alcohol ethoxylate tested)
- Details on test material:
- Ethoxylated alcohols (C12 with 3 or 6 EO)
Constituent 1
- Radiolabelling:
- other: partly
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: Oral / Dermal
- Vehicle:
- not specified
- Details on exposure:
- Various exposure routes and form of administration (for details see summary section)
- Duration and frequency of treatment / exposure:
- Various study periods (for details see summary section)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Various doses (for details see summary section)
- No. of animals per sex per dose / concentration:
- Various animal numbers (for details see summary section)
- Control animals:
- other: various (for detatils see summary section)
- Details on study design:
- Various test protocols
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, faeces, carcass, expired air, various tissues and organs
- Time and frequency of sampling: various
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Alcohol ethoxylates are readily absorbed in the gastrointestinal tract (>75% oral absorption following oral administration).
- Type:
- distribution
- Results:
- no significant distribution, no bioaccumulation
- Type:
- metabolism
- Results:
- two distinct polar metabolites detectable independent of ethoxylated alcohol investigated
- Type:
- excretion
- Results:
- Rapid and almost complete excretion ( 90% within first 24 hours; 98-99% within 72 hours)
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Alcohol ethoxylates of various C-chain length and ethoxylation degree are quickly and readiliy absorbed in the gastrointestinal tract following oral administration.
- Details on distribution in tissues:
- No indication of significant distribution in tissues and organs even at relatively high doses.
- Details on excretion:
- Rapid and almost complete excretion via urine, faeces and CO2. No dose-dependant differences in elimination observed.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- For each ethoxylated alcohol, two major polar metabolites were detected. Most probably resulting from the oxidization of the alcohol chain with the ethoxylate residue remaining intact.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Based on the very comparable toxicokinetic results with close structural analogous ethoxylated alcohols of various C-chain length and ethoxylation degrees, the registered ethoxylated alcohol is considered to be readily absorbed. Excretion is rapid and almost complete. - Executive summary:
Absorption, distribution, metabolism and excretion of different C14 -labelled ethoxylated alcohols (C12 with 3, 6 and 10 EO) was investigated in Wistar rats following oral and dermal exposure. Following administration the animals were placed in metabolism cages for 4 days and faeces, urine and expired air were monitored for C14 activity. At termination, various tissues, organs and the carcass were analysed for radioactivity. Relative amounts of test compounds found in urine, faeces, air and carcass did not differ significantly and recoveries were almost 100% for both exposure routes. The results suggests nearly complete absorption from the gastrointestinal tract for the shorter ethoxylate chain compounds whereas longer ethoxylate chain compounds may be partly excreted via bile or into the intestine by other routes. For each investigated ethoxylated alcohol, two distinct polar metabolites were detected in urine which are most probably resulting from the oxidization of the alcohol chain while the ethoxylate residue remains intact. In a separate study, the absorption, distribution and elimination kinetics of a C14 labelled C14 -18 fatty alcohol with 10 EO was investigated following single oral doses up to 1000 mg/kg body weight to Wistar rats. Urine, faeces and labelled CO2 were monitored daily over a period of 4 days. To investigate the distribution pattern, oesophagus, intestine, liver, kidney and blood were also monitored for C14 activity. Based on the results, a comparable kinetic behaviour to previous studies was observed. The ethoxylated alcohol was readily absorbed from the gastrointestinal tract with penetration rates of 80 - 90 %, elimination was rapid and almost complete and only very low levels of radioactivity were detected in the investigated organs. Based on all available reports, fatty alcohol ethoxylates of various chain length and ethoxylation degrees are absorbed quickly and extensively following oral exposure while dermal absorption is more slowly and incomplete. Elimination is rapid and almost complete whith urinary excretion being the major pathway with smaller amounts appearing in faeces (most probably due to biliary excretion) and CO2. From the toxicokinetic data, no indications of a bioaccumulative potential of ethoxylated alcohols exist.
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