Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-926-1 | CAS number: 227605-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to internationally accepted test guidance and good laboratory practices guidance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Principles of method if other than guideline:
- -Because of the loss of all 3 females at the 2000 mg/kg dose level, testing was continued at 200 mg/kg on August 11, 2000, with both sexes.
-Distilled water has been used as vehicle in this study instead of 0.5% (w/v) carboxymethylcellulose in 0.1% (w/v) aqueous polysorbate 80 (CMCPS 80). - GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- sodium 2-(azanidylsulfonyl)-3-(2,2,2-trifluoroethoxy)pyridine
- EC Number:
- 700-926-1
- Cas Number:
- 227605-94-9
- Molecular formula:
- C7H6F3N2NaO3S
- IUPAC Name:
- sodium 2-(azanidylsulfonyl)-3-(2,2,2-trifluoroethoxy)pyridine
- Reference substance name:
- Sodium {[3-(2,2,2-trifluoroethoxy)-2-pyridinyl]sulfonyl}azanide
- IUPAC Name:
- Sodium {[3-(2,2,2-trifluoroethoxy)-2-pyridinyl]sulfonyl}azanide
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): CA 3105 A (intermediate of CGA 362622)
- Substance type: Organic mono constituent substance
- Physical state: White solid
- Analytical purity: 93.9%
- Lot/batch No.: EZ001002
- Expiration date of the lot/batch: July 2002 (Re-analysis date)
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Hanlbm:WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd., Biotechnology & Animal Breeding Division, 4414 Füllinsdorf, Switzerland
- Age at study initiation: Young adult (approximately 7-11 weeks)
- Weight at study initiation: 170-213g
- Fasting period before study: Prior to dosing, the animals were fasted overnight.
- Housing: Macrolon Type 4 cages with soft wood bedding (Société Parisienne des Sciures, Patin, France); three same-sex animals per cage
- Diet (e.g. ad libitum): NAFAG No. 890 (NAFAG, Gossau/SG, Switzerland), available ad libitum. All batches of diet are assayed by the manufacturer to ensure proper nutritional content and absence of contaminants. A report of the assay for the diet batch used in a specific test is available.
- Water (e.g. ad libitum): Available ad libitum from bottles; source is municipal water supply. The water is examined four times a year by the government water authority (Baudepartement des Kantons Aargau, Abteilung Gewässerschutz). A report of an assay conducted about the time of the test is available on request.
- Acclimation period: At least five days before treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 50% ± 20%
- Air changes (per hr): Approximately 13-14/hour
- Photoperiod (hrs dark / hrs light): 12/12 hours
IN-LIFE DATES:
From: 2000 mg/kg- August 10, 2000 (females only); 200 mg/kg - August 11 , 2000 (both sexes) (Start of treatment)
To: 2000 mg/kg- August 10, 2000 (females only);200 mg/kg- August 25, 2000 (both sexes)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:
2000 mg/kg: 2.0002 g test article with vehicle ad 10 mL
200 mg/kg: 0.4013 g test article with vehicle ad 20 mL
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The high dose level of 2000 mg/kg was selected based on the OECD/EEC guidelines and pre-test results. - Doses:
- 200 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 2000 mg/kg: three females
200 mg/kg: three males and three females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical observations: Checked and recorded individually at 1, 3, 5, and 7 hours after dosing, then daily for the duration of the observation period.
Mortality: Checked twice daily, morning and afternoon.
Body weight: Measured and recorded immediately before dose administration, then on days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy observations
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 2000 mg/kg: two females (nos. 101 and 103) were found dead, and one female (no. 102) was sacrificed elected on the treatment day for animal welfare reason.
There was no mortality in the 200 mg/kg male and female groups. - Clinical signs:
- other: At 2000 mg/kg (females): slight Straub tail was seen in all females, slightly reduced activity and recumbency in two females (nos. 101 and 103), slight tonic convulsions in two females (nos. 101 and 102), and slight bilateral ptosis, slightly up to modera
- Gross pathology:
- At 2000 mg/kg: Necropsy examinations revealed a reddish small intestine in all females.
At 200 mg/kg: Necropsy examinations in the male and female groups revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The following acute oral LD50 values were determined:
LD50 in male rats: Greater than 200 mg/kg body weight.
LD50 in female rats: Greater than 200 mg/kg, lower than 2000 mg/kg body weight. - Executive summary:
Groups of 3 male and 3 female fasted Hanlbm:WIST (SPF) rats were administered a single dose of test substance by gavage at dose levels of 200 mg/kg (both sexes) and 2000 mg/kg (females only), followed by a 14-day post-treatment observation period.
At 2000 mg/kg, two females were found dead, and one female was sacrificed elected on the treatment day for animal welfare reason.
There was no mortality in the 200 mg/kg male and female groups.At 2000 mg/kg (females): Slight Straub tail was seen in all females, slightly reduced activity, recumbency, and slight tonic convulsions in two females, and slight bilateral ptosis, slightly up to moderately or markedly reduced activity, slightly hunched posture, slight abnormal gait, and paddling movements in one female on the treatment day.
At 200 mg/kg (males): Slightly reduced activity was observed in all males on the treatment day, which lasted in one male through day 2, slightly hunched posture in two males on the treatment day through day 2, and in one male on the treatment day through day 3, slight piloerection in all males on the treatment day, which lasted in one male through day 1. All males appeared normal on day 4 after treatment.
At 200 mg/kg (females): Slightly reduced activity, slightly hunched posture, and slight piloerection were seen in all females on the treatment day. All females appeared normal on day 1 after treatment.Body weights were not affected by treatment in any animals.
At 2000 mg/kg: Necropsy examinations revealed a reddish small intestine in all females.
At 200 mg/kg: Necropsy examinations revealed no observable abnormalities.The following acute oral LD50 values were determined for CA 3105 A (intermediate of CGA 362622):
LD50 in male rats: Greater than 200 mg/kg body weight.
LD50 in female rats: Greater than 200 mg/kg, lower than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.