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Diss Factsheets
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EC number: 242-687-1 | CAS number: 18936-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: study was documentation insufficient
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Principles of method if other than guideline:
- Male mice of ddY strain weighing about 25g were used throughout the experiment. The oral LD50 values for test were measured according to Weil (1952) using four animals per dose level and four different doses.
- GLP compliance:
- not specified
- Test type:
- other: acc. to Weil 1952
Test material
- Reference substance name:
- 2-methylbutyronitrile
- EC Number:
- 242-687-1
- EC Name:
- 2-methylbutyronitrile
- Cas Number:
- 18936-17-9
- Molecular formula:
- C5H9N
- IUPAC Name:
- 2-Methylbutyronitrile
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- weighing 25 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 4 animals per dose and 4 doses
- Control animals:
- not specified
- Details on study design:
- Weil, 1952
- Statistics:
- Hansch's model (Hansch and Fujita (1969) J Am Chem Soc 86: 1616-1626
Results and discussion
- Preliminary study:
- LD50 0,2153-0,3818
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.287 other: mmol/kg
- Based on:
- not specified
- 95% CL:
- 0.153 - 0.382
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- oral toxicity with LD50 0,2867 nmol/kg
lowest LD50 of 21 nitriles in mice tested in a comparative study - Executive summary:
The acute oral toxicity was determined in male mice. LD50 0,2867 mmol/kg
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