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Diss Factsheets
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EC number: 800-765-8 | CAS number: 1424149-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Overall assessment
The available data on Pentapropylensuccinic anhydride, reaction products with ethanolamine, sodium and triethanolamine salts comprise one Ames test, one HPRT test and one in-vivo MNT. Negative results were obtained in all available studies.
Since the Ames test comprised only four strains (TA97a, TA98, TA 100 and TA 102), missing the E-coli strain, the read-across approach was used to compensate for the uncertainty that may related to the missing the E-coli strain. No mutagenic effect was observed for the proposed source chemical in Ames test in S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2.
Read-across Justification
Both the target and the source chemicals are so called " product by process", in which the given raw materials and the process conditions are considered to be comparable, and the resulting products are considered to be comparable as well. The target chemical is a reaction mass of pentapropylensuccinic anhydride with ethanolamine/sodiumhydroxyde/triethanolamine, whereas the source chemical is a reaction mass of linear alkenyl (c12/14) succinic anhydride with methoxypropypamine/triethanolamine. For both processes, the anhydride moiety undergoes ring opening reaction, resulting in the formation of mainly amide and ester.
The structural difference for the target and source chemical is given in that the alkly moiety of the target chemical is branched and saturated whereas that of the source chemical is linear and unsaturated. The given difference is not likely to be related to significantly deviating mutagenic potential.
Justification for selection of genetic toxicity endpoint
All available data are considered to be equally valid and relevant for the assessment of genotoxicity
Short description of key information:
No significant genotoxicity found
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
All available data are indicative of low genotoxicity potential. No classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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