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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-661-7 | CAS number: 67-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for assessement
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data - List V
- Author:
- Smyth H.F., Carpenter C.P., Weil C.S., Pozzani U.C
- Year:
- 1 954
- Bibliographic source:
- Arch. ind. hyg. occupat. med. 10, 61-68.
Materials and methods
- Principles of method if other than guideline:
- Method: Draize Test
Eye injury in rabbits records the degree of corneal necrosis from various volumes and concentrations of chemical, as detailed by Carpenter and Smyth Am. J. Ophth. 29 :1363, 1946 - GLP compliance:
- no
- Remarks:
- pre-dates GLP
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- propan-1-ol
Analytical purity: No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Details on study design:
- Before instillation, the rabbit eyes were treated with 5% aqueous solution of fluorescein sodium. 20 sec later, the eyes were flushed with distilled water. After a 2 h interval to allow the eye to return to normal, 0.005 ml of the undiluted test substance is applied to the center of the cornea while the lids are retracted. About one minute later, the lids are released. This procedure is necessary to prevent the removal of a portion dose by the very efficient wiping system of the lids before intimate contact has been made with the eye. Eighteen to 24 h later, the eye is examined in strong diffuse daylight, then stained with fluorescein, and the injury scored. Guided by the result and a table of injury grades, additional applications are made until the chemical is assigned. If large volumes are applied, the lids are held closed for one minute before the animal is released.
Grade 1 in the table indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye ; Grade 5 indicates a so-called severe burn from 0.005 ml and grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.
Results and discussion
Any other information on results incl. tables
The test substance caused a grade 5 injury to the rabbit eye
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Highly irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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