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EC number: 696-318-8 | CAS number: 174489-43-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- prop-2-en-1-yl 2-(5-amino-2-chlorobenzoyloxy)-2-methylpropanoate
- EC Number:
- 696-318-8
- Cas Number:
- 174489-43-1
- Molecular formula:
- C14H16ClNO4
- IUPAC Name:
- prop-2-en-1-yl 2-(5-amino-2-chlorobenzoyloxy)-2-methylpropanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, 01400 Chatillon sur Chalaronne, France
- Age at study initiation: 2 - 3 months
- Weight at study initiation: 2020 - 2430 g
- Housing: Individual
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 50 % ± 20 %
- Air changes (per hr): 13 - 14 hour
- Photoperiod (hrs dark / hrs light): 12/12 hours
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
Volume applied: 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 males
- Details on study design:
Pre-treatment:
Approximately 24 hours before treatment, an area of approximately 10 cm wide from one flank to the other (across the back) of each animal shaved with an electric clipper.
Treatment:
The test article was applied to the shaved skin on one flank by means of a gauze patch (2 cm x 3 cm). A control patch was applied to the other flank. The patches were loosely covered with aluminium foil and held in place with adhesive tape. Control patches were moistened with distilled water to improve contact.
Post treatment:
4 hours after treatment, the dressings were removed and the area washed with lukewarm water to remove any remaining test article.
Scoring method:
EPA/OECD (Draize Scale)
Skin examinations:
1, 24, 48 and 72 hours after patch removal.
Clinical Observations:
Checked daily
Mortality:
Checked daily
Body weight:
Measured and recorded immediately before dose administration and at 72 hour examination (study end).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 to 72 hours
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 to 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 24 hours
- Irritant / corrosive response data:
Skin Examination:
Very slight erythema (score 1) was observed in two animals (no. 088 and 043) at the 1-hour examination. All skin reactions were fully reversed within 24 hours.
For results see Table 1.
Calculated skin irritation indices and scores according to OECD/EEC guidelines are presented in Table 2.- Other effects:
Mortality:
There was no mortality in the test.
Clinical Observations:
There were no remarkable clinical observations.
Body weights:
Body weights were not affected by treatment. Individual body weights presented din Table 3.
Classification:
According to Commission Directive 93/21/EEC, issued May 4, 1993, the results of this test indicate that CA 2219 A (Intermediate of CGA 276854) is not required to be classified for skin irritation.
Any other information on results incl. tables
Table1: Individual Dermal Irritation Scores (Draize)
ANIMAL NO. |
MALES |
||||||
088 |
043 |
166 |
|||||
|
ERYTHMA AND ESCHAR |
||||||
|
CF |
TF |
CF |
TF |
CF |
TF |
|
AFTER 1 HOUR AFTER 24 HOURS AFTER 48 HOURS AFTER 72 HOURS |
0 0 0 0 |
1 0 0 0 |
0 0 0 0 |
1 0 0 0 |
0 0 0 0 |
0 0 0 0 |
|
|
EDEMA |
||||||
AFTER 1 HOUR AFTER 24 HOURS AFTER 48 HOURS AFTER 72 HOURS |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
0 0 0 0 |
|
CF: CONTROL FLANK TF: TEST FLANK |
|||||||
Table 2: Summary Dermal Irritation Scores (OCED/EEC)
ANIMAL NO. |
MALES |
||||
|
088 |
043 |
166 |
||
|
ERTHYEMA AND ESCHAR |
||||
MEAN SCORE 24 – 72 HOURS |
0 |
0 |
0 |
||
OVERALL MEAN SCORE 24 – 72 HOURS |
0 |
||||
|
|||||
|
EDEMA |
||||
MEAN SCORE 24 – 72 HOURS |
0 |
0 |
0 |
||
OVERALL MEAN SCORE 24 – 72 HOURS |
0 |
||||
Table 3: Body Weights (g)
ANIMAL NO. |
MALES |
||
|
088 |
043 |
166 |
AT TEST START AFTER 3 DAYS |
2020 2080 |
2190 2270 |
2430 2440 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the test results, CA 2219 A (Intermediate of CGA 276854) is not required to be classified according to Commission Directive 93/21/EEC, issued May 4, 1993.
- Executive summary:
A dermal irritation/corrosion was conducted with test article CA 2219 A (Intermediate of CGA 276854) (batch 249-GE001/SU). The test article (0.5 ml) was applied to the shaved skin of three rabbits for four hours under occlusive conditions. The test sites were examined for skin irritation at 1, 24, 48 and 72 hours after patch removal.
The test article caused skin irritation in two animals. Very slight erythema was observed after the 1 hour examination. All skin reactions were fully reversed within 24 hours after patch removal. There was no mortality, and there were no remarkable clinical observations. Body weights were not affected by treatment.
Calculation of mean scores for individual animals (EEC method, 24 – 72 hours) for erythema and eschar, and edema resulted in scores of 0, with an overall mean of 0.
According to the test results, CA 2219 A (Intermediate of CGA 276854) is not required to be classified according to Commission Directive 93/21/EEC, issued May 4, 1993.
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