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EC number: 211-623-4 | CAS number: 675-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 May 2002 to 26 July 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (1996)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- FREIE UND HANSESTADT HAMBURG, BEHÖRDE FÜR ARBEIT, GESUNDHEIT UND SOZIALES, Hamburg, Germany
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dichloromethyl(3,3,3-trifluoropropyl)silane
- EC Number:
- 211-623-4
- EC Name:
- Dichloromethyl(3,3,3-trifluoropropyl)silane
- Cas Number:
- 675-62-7
- Molecular formula:
- C4H7Cl2F3Si
- IUPAC Name:
- (dichloromethyl)(3,3,3-trifluoropropyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Silane 2813, Wacker-Chemie GmbH Test Substance No . 60018428, Receipt No. 24753
- Substance type: chlorosilane
- Physical state: colourless liquid
- Odour: none (according to LPT), pungent (according to sponsor)
- Batch No.: QB15034
- Expiration date of the lot/batch: 01-01-2004
- Stability under test conditions: stability in vechicle (corn oil) at +4°C in dark: > 1 day
- Storage condition of test material: at room temperature, dark, tightly closed, dry, no contact with oxygen
- Stability under storage conditions: at + 25 °C > 1 year
- Density: 1.27 g/cm³
- Date of Receipt: 2002-04-17
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Crl:CD
- Source: Charles River Deutschland GmbH, Sandhofer Weg 7, D-97633 Sulzfeld
- Age at study initiation: 42 days (males), 50 days (females).
- Weight at study initiation: 170-194 g (males), 175-183 g (females)
- Fasting period before study: 16 hours
- Housing: Animals were kept in groups of 2-3 in Makrolon cages (types III). Granulated textured wood (Granulate A2, J. Brandenburg, D-49424 Goldenstedt) was used as bedding material for the cages.
- Diet: Ssniff R/M-H V 1530 (ssniff spezialdiaten GmbH, D-59494 Soest) served as food. Feed was discontinued approx. 16 hours before administration;only tap water was then available ad libitum.
- Water: Drinking water in bottles was offered ad libitum.
- Acclimation period: At least 5 adaptation days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 55±15
- Photoperiod (hrs dark / hrs light): The rooms were lit (about 150 lux at approx. 1.50 m room height) and darkened for periods of 12 hours each.
IN-LIFE DATES: From:13 May 2002 to: 26 June 2002
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Remarks:
- Corn oil was used as vehicle for the 200 mg/kg dose only.The test substance was used as supplied for the 2000 mg/kg dose.
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1.57 mL/kg bw
- Doses:
- 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 males - 2000 mg/kg bw.
3 males and 3 females -200 mg/kg bw. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed before and immediately, at 5, 15, 30 and 60, as well as at 3, 6 and 24 hours after administration. Observation on mortality was made at least once daily. Individual body weights were recorded before administration of the substance and thereafter in weekly intervals up to the end of the study, and at death.
- Necropsy of survivors performed: yes. At the end of the experiment (in the morning of test day 15), all surviving animals were sacrificed, dissected and inspected macroscopically. From animals which survived 24 hours or longer, a microscopic examination of all organs which showed evident lesions was performed. Autopsy and macroscopic inspections of animals which died prematurely were carried out as soon as possible after exitus.
- Other examinations performed: organ weights, histopathology, changes of skin and fur, eyes and mucous membranes, respiratory and the circulatory, autonomic and central nervous system, somatomotor activity as well as behaviour pattern were observed. - Statistics:
- No statistical analysis was performed (The method used was not intended to allow the calculation of a precise LD50 value).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 range given in the study report
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The LD50 cut-off value was determined on the basis of the interpretation flowchart of the followed OECD guideline.
- Mortality:
- 2000 mg/kg bw resulted in the death of two male CD rats within 4 days.
200 mg/kg bw resulted in the death of one male and one female CD rat within 4 days. - Clinical signs:
- other: No signs of systemic toxicity were noted at both 2000 and 200 mg/kg bw (See tables 1 & 2 for detail).
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
Any other information on results incl. tables
Table 1. Results summary
Symptoms/ criteria |
2000 mg/kg bw |
200 mg/kg bw |
||
Male (n = 3) |
|
Male (n = 3) |
Female (n = 3) |
|
Animal with no intolerance reactions |
3 |
- |
3 |
3 |
Mortality |
|
|
|
|
Within 6 hours |
0 |
- |
0 |
0 |
Within 2 days |
0 |
- |
0 |
0 |
Within 7 days |
2 |
- |
1 |
1 |
Within 14 days |
2 |
- |
1 |
1 |
Mean weight in g |
|
|
|
|
Start |
190.3 |
- |
175.7 |
180.0 |
After 7 days |
247.0 (+ 29.3) |
- - |
230.5 (+ 31.5) |
225.0 (+ 26.1) |
After 14 days |
264.0 (+ 38.2) |
- - |
295.0 (+ 69.3) |
231.0 (+ 29.4) |
Inhibition of body weight gain |
None |
- |
None |
None |
Autopsy findings |
None |
- |
None |
None |
- = not observed In brackets = body weight gain in %
Table 2. Clinical signs / Individual data
Clinical Signs |
|||||||||||||
Test day |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
2 |
3 |
4 |
5-14d |
||
Time after Administration |
0 |
5’ |
15’ |
30’ |
60’ |
3h |
6h |
24h |
|
|
|
||
Animal no./sex
|
Clinical signs
|
|
|||||||||||
2000 mg silan 2813 /kg bw |
|||||||||||||
1 m |
None |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
2 m |
Death |
- |
- |
- |
- |
- |
- |
- |
- |
* |
|
|
|
3 m |
Death |
- |
- |
- |
- |
- |
- |
- |
- |
- |
* |
|
- = not observed * = animal died prematurely m = Male
Table 3. Clinical signs / Individual data
Clinical Signs |
|||||||||||||
Test day |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
2 |
3 |
4 |
5-14d |
||
Time after Administration |
0 |
5’ |
15’ |
30’ |
60’ |
3h |
6h |
24h |
|
|
|
||
Animal no./sex
|
Clinical signs
|
|
|||||||||||
200 mg silan 2813 /kg bw |
|||||||||||||
4 m |
None |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
5 m |
death |
- |
- |
- |
- |
- |
- |
- |
- |
* |
|
|
|
6 m |
None |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
7 f |
None |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
8 f |
Death |
- |
- |
- |
- |
- |
- |
- |
- |
- |
* |
|
|
9 f |
None |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- = not observed * = animal died prematurely m = Male f = Female
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study conducted according to the OECD TG 423, and in compliance with GLP, an LD50 range of 200-2000 mg/kg bw was identified. 2000 mg/kg bw resulted in the death of two male CD rats within 4 days. No signs of systemic toxicity were noted at 2000 mg/kg bw. 200 mg/kg bw resulted in the death of one male and one female CD rat within 4 days. No signs of systemic toxicity were noted at 200 mg/kg bw.
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