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EC number: 232-191-3 | CAS number: 7789-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance calcium iodate is classified as irritating to skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Dictionary of Substances and their effects (DOSE) database
- GLP compliance:
- not specified
- Species:
- human
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period:
- no data
- Number of animals:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: Irritating to humans
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Potassium iodate is found to be irritant to skin and mucous membranes of humans
- Executive summary:
Potassium iodate is found to be irritant to skin and mucous membranes of humans
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- other: human; rabbit
- Strain:
- other: not applicable
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- other: Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells.
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.
- Executive summary:
Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells. The substance is classified in eye irritation Category 2A as per the CLP criteria.
Reference
Estimation
method: Taking highest mode value from the 5 nearest neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -7.18
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -7.18
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Based on studies of read across chemicals reviewed for skin irritation from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No |
End point |
effect |
Species |
Remark |
1 |
Overall irritation score |
irritating |
humans |
Data is from DOSE for CAS NO 7758-05-6 |
2 |
Overall irritation score |
moderately irritating |
rabbit |
Data is from publication CAS NO 7681-82-5 |
Thus by applying weight of evidence approach to the studies summarized in the above table it can be concluded that the substance is irritating to the skin of human and rabbit. Thus Calcium iodate was considered to be skin irritant as the criteria of CLP regulation
Eye irritation:
Based on studies of target substance calcium iodate and read across reviewed for eye irritation from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach
The summary of the results are presented below
Sr. No |
End point |
effect |
Species |
Remark |
1 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Predicted data for target chemical |
2 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Data from publication for CAS: 7758-05-6 |
3 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Data from publication for CAS: 7758-05-6 |
4 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Data from publication for CAS: 7758-05-6 |
5 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Data from publication for CAS: 7758-05-6 |
6 |
Other |
retinal toxicity that damages RPE and photoreceptor cells
|
Humans |
Data from publication for CAS: 7758-05-6 |
Based on the results summarized in above tables for the target chemical Calcium iodate and read across, it can be concluded that the substance causes retinal toxicity that damages RPE and photoreceptor cells in humans.Thus based on this results Calcium iodate is considered to be irritant as the criteria for CLP regulation.
Justification for selection of skin irritation / corrosion endpoint:
Potassium iodate is found to be irritant to skin and mucous membranes of humans
Justification for selection of eye irritation endpoint:
Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
According to new CLP regulation classification criteria and based on the values of skin and eye irritation, it is concluded that the substance calcium iodate is not classified as skin irritation category 2 and eye irritation Category 2A.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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