Registration Dossier
Registration Dossier
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EC number: 241-972-8 | CAS number: 18063-03-1
Endpoint summary
Administrative data
Description of key information
2,6-Difluorobenzamide was found to be not irritating to the skin and eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
In a skin irritation test according to OECD guideline 404, 500 mg of 2,6-difluorobenzamide was applied to 2 cm x 2cm of the skin of New Zealand White rabbits (3/sex) as a moistened powder for 4 hours under semi-occlusive conditions after which the substance was removed by washing (Sittingbourne Research Centre, 1987). Observations were done at 30 minutes, 24, 48 and 72 hours and 7 days after patch removal. The erythema and edema scores were 0 on a scale of 0 to 4 for each observation time point. The substance was judged as being not irritating to skin.
Eye irritation
In an eye irritation test according to OECD guideline 405, 2,6-difluorobenzamide was applied as 25 mg of powder to the conjunctival sac of one of the eyes of New Zealand White rabbits (3/sex) (Sittingbourne Research Centre, 1987). The eyes were not washed thereafter. A visual assessment of the eyes was performed at 1, 4-7, 24, 48 and 72 hours and 7 days after instillation. No effects on any of the eye irritation parameters (cornea, iris, chemosis and conjunctivae score) were observed nor was there any indication of an initial pain response. The substance was judged as being not irritating to the eyes.
Justification for classification or non-classification
Based on the results of the skin and eye irritation tests, 2,6-difluorobenzamide does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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