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EC number: 201-972-0 | CAS number: 90-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from experimental report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modified Federal Hazardous Labelling Act
- Principles of method if other than guideline:
- The test was designed to investigate the irritation effects of test chemical when applied to the one eye of single rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2,2-trichloro-1-phenylethyl acetate
- EC Number:
- 201-972-0
- EC Name:
- 2,2,2-trichloro-1-phenylethyl acetate
- Cas Number:
- 90-17-5
- Molecular formula:
- C10H9Cl3O2
- IUPAC Name:
- 2,2,2-trichloro-1-phenylethyl acetate
- Details on test material:
- - Name of test material (as cited in study report): 2,2,2-trichloro-1-phenylethyl acetate (rosacetone)
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Age at study initiation: aged 7-9 weeks
- Weight at study initiation:weighing between 1-2 Kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 10 mg
- Duration of treatment / exposure:
- 24 hrs.
- Observation period (in vivo):
- 15 min. after application
24 hrs. after application
daily intervals for 5 days per week for 3 weeks - Number of animals or in vitro replicates:
- 6 animals
- Details on study design:
- The lower eyelid is gently pulled away from the globe and 10 mg of test substance applied into the cup so formed ;the eyelid then release. The rabbit was inspected with hand torch before any treatment and those with spontaneous eye lesions are rejected.Flurescein is applied to eye to assist in the detection of corneal lesions.Corneal thickness is also measured before the application ot test material
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- other: Not applicable
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test chemical caused no corneal, conjunctival, or iridial damage 24 hours after treatment.
Any other information on results incl. tables
Table 1: Summary of test result
Experimental group |
No of rabbits |
Discomfort |
Number of rabbits with stated ocular lesion |
|||||||||||||
Positive conjunctival reactions |
No. with iritis |
No. with pannus |
Maximum corneal opacity |
Duration of opacity |
Maximum corneal swelling |
|||||||||||
0.5 |
1 |
2 |
3 |
4 |
>1 on day 8 |
>0.5 on day 8 |
Nil (0-10%) |
Slight (11-45%) |
Moderate (46-80%) |
Severe (81%+) |
||||||
A |
1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
1 |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- The test chemical caused no corneal, conjunctival, or iridial damage 24 hours after treatment at concentration of 10mg. Hence, the test material can be considered to be not irritating to New Zealand White rabbit eyes.
- Executive summary:
An eye irritation study was conducted in accordance with Modified Federal Hazardous Labelling Act Method by using a single rabbit.
The rabbit was inspected with a hand torch before any treatment and those without any serious corneal lesions were taken. Corneal thickness was also measured before the start of the test. The lower eyelid was gently pulled away from the globe and 10 mg of test substance applied on one eye into the cup so formed; the eyelid was then released.
Animal was watched during and immediately after the application of the test chemical. 15 minutes after the application of the test chemical the eyes were observed for conjunctival reactions. One day after the application of test material and then at daily intervals for five days per week for three weeks or until the eye is completely clear. Fluorescein was applied to eyes to assist in the detection of corneal lesions.
Each day after application of the test chemical, the corneal thickness was measured using a slit lamp. Corneal swelling was expressed as:
(Corneal thickness on day of measurement)/(Corneal thickness on before treatment)-1)*100%.
The test chemical caused no corneal, conjunctival, or iridial damage 24 hours after treatment at tested concentration of 10 mg.
Hence, the test chemical can be considered to be not irritating to New Zealand White rabbit eyes.
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