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EC number: 249-220-0 | CAS number: 28783-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 25 july 1995 to 31 July 1995
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD guideline but no data on GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
- IUPAC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
- Reference substance name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride
- EC Number:
- 249-220-0
- EC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride
- Cas Number:
- 28783-41-7
- Molecular formula:
- C7H9NS.ClH
- IUPAC Name:
- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- The test article used in this study was PCR 0665 (4,5,6,7 Tetrahydrothieno-(3,2-c) Pyridine, Hydrochloride) batch 3SNL502. No control article was used; untreadted sites served as controls. The powdered material was provided by the Toxicology Pharmacy in envelopes with 500 mg/envelope for the cutaneous irritation portion of the study. Since pure drug substance was used in this study, no analyses were required.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Three New Zealand White rabbits, one male and two females, five to six months old were obtained from Hazleton Research Products, Inc., identified by vendor- attached plastic ear tag or implanted microship and study animal identification number written with indelible ink pen inside the right ear, and housed one per cage. Prior to and during the study, the rabbits were caged in an environmentally controlled room maintained at approximately 64-68°F, 40-60% relative humidity, and 12 hour light/dark cycles. The rabbits were provided with approximately 125 grams/rabbit/day of Purina Cartified High Fiber Rabbit Chow No. 5325 lot 17 May 95 2A and 15 June 95 1B and municipal water (via an automatic watering system) ad libitum. The rabbits were weighed on Day-1 and weights ranged from 2.8 to 3.3 kg.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated left side of the animal served as control for skin irritation study.
- Amount / concentration applied:
- 500 mg of solid compound
- Duration of treatment / exposure:
- Approximately 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
No clinical signs of toxicity were observed in any rabbit and no deaths occured during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dermal application of PCR 0665 did not produce any adverse reactions.
Based on the results of this study, PCR 0665 does not meet the R-rating criteria for skin irritation.
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