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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 June 2014-07 September 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report date:
2014

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
(2009)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
(2006)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Remarks:
(isothermal thermogravimetry)

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl DL-serinate hydrochloride
EC Number:
227-047-1
EC Name:
Methyl DL-serinate hydrochloride
Cas Number:
5619-04-5
Molecular formula:
C4H9NO3.ClH
IUPAC Name:
methyl 2-amino-3-hydroxypropanoate hydrochloride
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): DL-serine Methylester HCl
- Molecular formula: C4H9NO3.HCl
- Molecular weight: 155.58 g/mol
- Description: White crystalline powder
- Storage condition of test material: At room temperature in the dark
- Expiration date of the lot/batch: 14 September 2014

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
< 1.5 other: E-03 Pa
Temp.:
25 °C
Vapour pressure:
< 9.6 other: E-03 Pa

Any other information on results incl. tables

The weight loss of the test substance was effected by the weight of the sample and the weight loss curves were not linear. Both are an indication that reaction and/or degradation occurred during the study.

 

The test substance weight losses measured at 100°C, 110°C, 120°C and 130°C were lower than the weight losses of hexachlorobenzene at the same temperatures. Based on this, it could be safely concluded that vapour pressure of the test substance is lower than the vapour pressure of hexachlorobenzene.

Applicant's summary and conclusion

Conclusions:
In a GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950 using the isothermal thermogravimetric effusion method, the vapour pressure of the substance has been determined as < 9.6E-03 Pa at 25°C (<1.5E-03 Pa at 20°C).