3,3'-oxybis(ethyleneoxy)bis(propylamine)

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VII

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30: 470-476

Materials and methods

Principles of method if other than guideline:

Eye injury in rabbits was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that resulted from instillation of various volumes and concentrations of a chemical. Grade 1 indicates at most a very small area of necrosis resultig from 0.5 mL of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 mL, and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,3'-oxybis(ethyleneoxy)bis(propylamine)

EC Number:

224-207-2

EC Name:

3,3'-oxybis(ethyleneoxy)bis(propylamine)

Cas Number:

4246-51-9

Molecular formula:

C10H24N2O3

IUPAC Name:

3,3'-[oxybis(ethane-2,1-diyloxy)]dipropan-1-amine

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

No data

Test system

Details on study design:

Eye injury in rabbits was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that resulted from instillation of various volumes and concentrations of a chemical. Grade 1 indicates at most a very small area of necrosis resultig from 0.5 mL of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 mL, and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol.

Results and discussion

In vivo

Results

Irritation parameter:

other: Corneal injury

Score:

8

Max. score:

10

Reversibility:

not specified

Remarks on result:

other: according to: Carpenter, C.P. & Smyth, H.F. (1946): Chemical Burns of the Rabbit Cornea. Am. J. Ophthal. 29: 1363.

Irritant / corrosive response data:

Corneal injury in rabbits Grade 8 (= excess of 5% solution gives injury of up to 5.0 points (15% gives over 5.0); see Carpenter, C.P. & Smyth, H.F.: Chemical Burns of the Rabbit Cornea. Am. J. Ophthal. 29: 1363 (Nov. 1946)).

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

A corneal injury of Grade 8 was recorded, indicating severe, irreversible damage to rabbit's eye under the tested conditions.

Executive summary:

Eye injury in rabbits was recorded in a 10-grade ordinal series and was based upon the degree of corneal necrosis that resulted from instillation of various volumes and concentrations of a chemical. Grade 1 indicates at most a very small area of necrosis resultig from 0.5 mL of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 mL, and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol. Under the conditions of this study, corneal injury of Grade 8 (= excess of 5% solution gives injury of up to 5.0 points (15% gives over 5.0); see Carpenter, C.P. & Smyth, H.F.: Chemical Burns of the Rabbit Cornea. Am. J. Ophthal. 29: 1363 (Nov. 1946)) was recorded, indicating severe eye damage.