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EC number: 203-236-4 | CAS number: 104-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a study performed according to a protocol comparable to the OECD Guideline 401, the oral LD50 was 830 mg/kg bw in rat. In an acute dermal toxicity study performed according the OECD guideline #402, the dermal LD50 was 0.64 (0.39-1.04)ml/kg(524 mg/kg)in male New Zealand rabbit. In a inhalation risk test, no mortality was observed after a 4h-exposure to saturated vapours.
Oral toxicity
In a key study comparable to the OECD no. 401 Guideline (BASF AG, 1981), test groups of 5 or 10 rats were treated by single gavage application with an aqueous solution of 3-aminopropyldiethylamine. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated to be ca. 830 mg/kg on the basis of the observed mortalities.
The acute oral toxicity of 3-aminopropyldiethylamine (DEAPA) was evaluated in rats according to a protocol similar to OECD no. 401 guideline (Myers and Ballantine, 1997). Groups of 5 male Wistar albino rats were given a single oral dose of DEAPA. Following treatment, rats were observed daily. Animals were weighted before treatment and 14 days after dosing, time of scheduled euthanasia. No other data is available but under these experimental conditions, the oral LD50 of DEAPA is 0.50 ml/kg (0.26-0.76 ml/kg) or 410 mg/kg (213 -623) in Wistar rats with 95% confidence interval limits.
The acute oral toxicity of 3-aminopropyldiethylamine (DEAPA) was evaluated in groups of five male Carworth-Wistar rats (Smyth et al., 1962). No precise data are available, but under these experimental conditions, the oral LD50 of DEAPA is 1410 mg/kg (1210-1650mg/kg) in male rats with 95% confidence interval limits.
Inhalation toxicity
Data were available from an inhalation risk test (IRT) which meets generally accepted scientific principles (BASF AG, 1961). The toxicity of an atmosphere saturated with vapours of the volatile components of 3-aminopropyldiethylamine at the temperature chosen for vapour generation (20 °C) was evaluated in 3 or 6 rats per sex exposed sequentially to the vapours, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 30 min, 2 h and 8h. The documentation of clinical signs was performed over a period of 7 days. No mortality was observed after a 30-min exposure. One female died within 24 h after a 2h-exposure and 1 male and 2 females died within 24 h after a 8h-exposure.
In 2 other IRT (Myers and Ballantyne, 1997; Smyth et al., 1962), the inhalation of a saturated vapor-air mixture for 4 or 8 hours caused no mortality.
Dermal toxicity
The acute dermal toxicity of 3-aminopropyldiethylamine was evaluated in five male New Zealand white rabbits (Myers and Ballantyne, 1997). The test substance was applied under an impervious plastic sheeting wrapped around the trunk and secured. The rabbit was then immobilized into a restraining apparatus for 24 hours. Animals were observed during 14 days. No other data is available. Under these experimental conditions, the dermal LD50 was 0.64 ml/kg (524 mg/kg) in male rabbits.
The acute dermal toxicity of 3-aminopropyldiethylamine (DEAPA) was evaluated in groups of four white New-Zealand rabbits (Smyth et al., 1962). No precise data are available, but under these experimental conditions, the LD50 was 0.75 ml/kg (615 mg/kg).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May 1961 - 15 Jun 1961
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Meyer-Arend rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 153 g (mean) - Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 400, 800, 1000, 1250 or 1600 cmm/kg bw (166, 322, 664, 830, 1037.5, 1328 mg/kg bw - conversion in mg/kg is based on density: d=0.83 g/cm3 (BASF AG MSDS)
- No. of animals per sex per dose:
- 166, 322, 644 mg/kg: 2 males, 3 females.
830 mg/kg: 4 females, 6 males.
1037.5 mg/kg: 4 males, 6 females.
1328 mg/kg: 2 males, 3 females. - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 830 mg/kg bw
- Mortality:
- 1328 mg/kg: all animals died within 24 h.
1037.5 mg/kg: 4 females died within 24 h and 1 male within 48 h.
830 mg/kg: 3 males and 1 female died within 24 h. 1 male died within 3 days and 1 male within 6 days.
644 mg/kg: 1 male died on day 7. - Clinical signs:
- other: 1328 mg/kg: staggering, beginning lameness of hind limbs, apathy, abdominal position, accelerated respiration. 1037.5 mg/kg: apathy, ruffled fur. 870 mg/kg: ruffled fur, animals were calmer as usual. 644 mg/kg: calmer as usual.
- Gross pathology:
- 1328 mg/kg: 3x stomach filled with red-yellowish content.
1037.5 mg/kg: 1x stomach filled with red-yellowish content, congested liver.
830 mg/kg: 3x stomach filled with red-yellowish content, 2x congestion of liver, spleen and kidneys. 1x small intestine reddened, diarrhoea. 1x fundus reddened.
644 mg/kg: congestion of the lung, distinct peritonitis.
Sacrificed animals:
644 mg/kg: 1x slight paleness of kidney. - Interpretation of results:
- Toxicity Category IV
- Executive summary:
In a study comparable to the OECD Guideline 401, test groups of 5 or 10 rats were treated by single gavage application with an aqueous solution of 3 -aminopropyldiethylamine. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was estimated to be ca. 830 mg/kg on the basis of the observed mortalities.
Reference
Mortality:
Dose (mg/kg bw) | conc. (%) | 1 h | 24 h | 48 h | day 7 | day 14 |
1328 | 20 | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 |
1037.5 | 10 | 0/10 | 4/10 | 5/10 | 5/10 | 5/10 |
830 | 10 | 0/10 | 4/10 | 4/10 | 6/10 | 6/10 |
644 | 8 | 0/5 | 0/5 | 0/10 | 1/10 | 1/10 |
322 | 8 | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 |
166 | 2 | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 |
There is indication that the test substance causes local irritation to exposed tissues.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 830 mg/kg bw
- Quality of whole database:
- Acceptable, well-documented report which meets basic scientific principles.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2e
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation risk-test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
by passing 2.5L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 mL of the test chemical contained in a gas-washing bottle. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- saturated vapor
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- male/female
- Effect level:
- other: atmosphere saturated with vapours
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality
- Mortality:
- No mortality at saturated vapor for 4 hours
- Clinical signs:
- other: No data
- Body weight:
- No data
- Gross pathology:
- No data
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality at saturated vapor for 4 hours.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Collection of data
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 3-5 months
- Weight at study initiation: 2-3kg
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): ad libitum commercialdiet
- Water (e.g. ad libitum): ad libitum municipal water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Fur was carefully removed from the ventral skin, using an electric clipper. Test substance was applied and impervious plastic sheeting was wrapped around the trunk and secured.
The rabbit was immobilized into a restraining apparatus for 24 hours. - Duration of exposure:
- 24 hours
- Doses:
- No data
- No. of animals per sex per dose:
- 5 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations : daily
- Weighing D1, 14
- Necropsy of survivors performed: yes - Statistics:
- method of Thompson, tables of Weil
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.64 mL/kg bw
- 95% CL:
- 0.39 - 1.04
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 524 mg/kg bw
- 95% CL:
- 320 - 853
- Remarks on result:
- other: based on a density of 0.82
- Mortality:
- time to death=1d
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Interpretation of results:
- Toxicity Category III
- Conclusions:
- The dermal LD50 was 524 mg/kg in male rabbits.
- Executive summary:
The Acute dermal toxicity of 3 -aminopropyldiethylamine was evaluated in five male New Zealand white rabbits. The test substance was applied under an impervious plastic sheeting wrapped around the trunk and secured. The rabbit was then immobilized into a restraining apparatus for 24 hours. Animals were observed during 14 days.
No other data is available. Under these experimental conditions, the dermal LD50 was 0.64 ml/kg (524 mg/kg) in male rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 524 mg/kg bw
- Quality of whole database:
- Data from handbook
Additional information
Justification for classification or non-classification
According to the harmonised classification and labelling(CLP) approved by the European Union:
- Acute Tox. 4 * H302
- Acute Tox. 4 * H312
Self classification according to CLP criteria:
- Acute Tox. 4 H302
- Acute Tox. 3 H311
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