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EC number: 604-669-5 | CAS number: 149021-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-01-11 to 2008-02-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to OECD TG No. 405 and in compliance with GLP regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-propylheptyl acrylate
- EC Number:
- 604-669-5
- Cas Number:
- 149021-58-9
- Molecular formula:
- C13 H24 O2
- IUPAC Name:
- 2-propylheptyl acrylate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material: 2-Propylheptylacrylat rein
- Test substance number: 07/0846-1
- Analytical purity: 98.5 area-%
- Isomers composition: about 87 % 2 Propylheptylacrylate and 10 % 4-methyl-2-propylhexylacrylate
- Analytical report no.: 07L00384
- Lot/batch No.: B4112/13 - 03122007
- Expiration date of the lot/batch: 2008-12-03
- pH-value: Ca. 5.5 (undiluted test substance)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Rabbits / New Zealand white A 1077 INRA (SPF) from Centre Lago S. A., 01540 Vonnas, France
- Age at study initiation: 5 – 6 months
- Weight at study initiation: 3.52 kg – 4.03 kg
- Housing: Stainless steel wire mesh cages with grating, floor area: 3000 cm². Single housing.
- Diet: Kliba-Labordiaet (Kaninchen & Meerschweinchenhaltung “GLP”), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland (about 130 g/animal per day)
- Water: Tap water ad libitum
- Acclimation period: at least 5 days before application
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 30-70%
- Photoperiod (hrs dark / hrs light): 12 h / 12 h (6.00 a.m. – 6.00 p.m. / 6.00 p.m. – 6.00 a.m.)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated left eye of the animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL
- Concentration: undiluted - Duration of treatment / exposure:
- Exposure for 24 h.
- Observation period (in vivo):
- 72 h (the study was discontinued since all animals were without findings 48 h after test start)
- Number of animals or in vitro replicates:
- 3 animals (2 female, 1 male)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: rinsed with 3 to 6 mL of hand warm tap water for 1 to 2 minutes using a syringe with a blunt probe.
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize scoring system according to OECD Tg 405
TOOL USED TO ASSESS SCORE:
-Daylight tubes "Lumilux" (L 58W/860 PLUS ECO 25X1, Osram, Germany)
Readings:
Approx. 1, 24, 48 and 72 h after application.
Mortality check:
A check for any dead or moribund animal was made twice each workday (at the beginning and end of work) and once daily at weekends and on public holidays.
Evaluation/Scoring:
The evaluation is based on the criteria of the Commission Directive 67/548/EEC and the OECD Harmonized Integrated Classification System that were in place on the date of report signature.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effect
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24-72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- Moderate conjunctival redness (grade 2) was noted in all animals 1 hour after application and decreased to slight (grade 1) in one animal until the 24-hour reading. Moderate or severe discharge (grade 2 or 3) was noted in all animals 1 hour after application, only. In addition injected scleral vessels ina circumscribed area or circular were noted during the observation period.
The ocular reactions were reversible in two animals within 24 hours and in one animal within 48 hours after application.
Mean scores calculated for each animal over 24, 48 and 72 hours were 0.0 for corneal opacity and for iris lesions, 0.0, 0.0 and 0.3 for redness of the conjunctiva and 0.0 for chemosis. (see details in table 1)
Any other information on results incl. tables
Table 1: Individual ocular examinations and mean values.
Readings |
Animals |
Cornea |
|
Iris |
Conjunctiva |
|
|
Additional findings |
|
|
Opacity |
Area of cornea involved |
|
Redness |
Chemosis |
Discharge |
|
1 h |
1 |
0 |
0 |
0 |
2 |
0 |
0 |
scleral vessels injected, circumscribed area |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
2 |
0 |
0 |
scleral vessels injected, circular |
|
24 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
1 |
0 |
0 |
scleral vessels injected, circumscribed area |
|
48 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
72 h |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
3 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Mean 24-72 h |
1 |
0.0 |
|
0.0 |
0.0 |
0.0 |
0.0 |
|
2 |
0.0 |
|
0.0 |
0.0 |
0.0 |
0.0 |
|
|
3 |
0.0 |
|
0.0 |
0.3 |
0.0 |
0.0 |
|
|
Mean |
|
0.0 |
|
0.0 |
0.1 |
0.0 |
0.0 |
|
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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