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EC number: 611-025-7 | CAS number: 53651-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-06-16 to 1994-06-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted on February 24, 1987
- Deviations:
- yes
- Remarks:
- , a slight deviation on the humidity levels, which sometimes exceeded the upper limit of 70% given in the guideline
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- propyl (2S)-2-hydroxypropanoate
- EC Number:
- 611-025-7
- Cas Number:
- 53651-69-7
- Molecular formula:
- C6H12O3
- IUPAC Name:
- propyl (2S)-2-hydroxypropanoate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): n-propyl lactate
- Analytical purity: 99.5%
- Lot/batch No.: 3
- Appearance: clear, colourless liquid
- Storage conditions: ambient
TREATMENT OF TEST MATERIAL PRIOR TO TESTING:
undiluted
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan/CPB, Austerlitz, The Netherlands
- Age at study initiation: 5-6 weeks
- Housing: 5 animals/cage (stainless steel cages, fitted with wire-screen floor and front)
- Diet: standard laboratory diet, ad libitum
- Water: tap water, ad libitum
- Acclimation period: 45 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 59-92.5
- Air changes (per hr):10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: no vehicle used
MAXIMUM DOSE VOLUME APPLIED: 2 mL/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical symptoms were recorded once daily; body weights were measured on day 3, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathology, the abdomen and the thorax were examined - Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: The only clinical symptom observed was sluggishness 1 and 4 h post-treatment, in all rats.
- Body weight:
- other body weight observations
- Remarks:
- All animals gained weight during the 14-day observation period
- Gross pathology:
- No treatment-related gross alterations were observed.
- Other findings:
- No other findings were observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Propyl (S)-lactate is not acutely toxic when administered to rats by gavage, at a single dose of 2000 mg/kg bw. The LD50 is greater than 2000 mg/kg bw for both sexes.
- Executive summary:
In an acute oral toxicity study conducted according to OECD guideline 401, groups of Wistar rats (5/sex) were given propyl (S)-lactate (purity 99.5%) as a single oral dose of 2000 mg/kg bw. The animals were observed for 14 days after the single exposure. No mortalities and no further signs of toxicity occurred. Therefore, the oral LD50 is greater than 2000 mg/kg bw, both in male and female rats.
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