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EC number: 500-465-4 | CAS number: 160901-28-0 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 18 Jan 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Computational Approach in OECD Guideline 107 (EU A.8)
- Principles of method if other than guideline:
- According to the guidance of the ECHA a ratio calculation is an acceptable alternative for the determination of octanol/water Partition Coefficient of surfactants.
Citation from ''Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance'', R.7.1.8 Partition Coefficient, page 102:
This method enables partition coefficient to be calculated based on the ratio of the solubility of the material in octanol and water. For some substances (e.g. some surfactants and pigments), it is technically not feasible (or good practice) to measure an octanol-water partition coefficient by OECD 107, and other methods (OECD 117 and QSAR) may be unsuitable as they are based on extrapolations of measured values. For such substances it may be possible to obtain a ratio of the saturated water solubility (OECD 105) and saturated octanol solubility (no guideline currently available but based on the principles of OECD 105). The calculation method however has the drawback that it does not include the interaction between the water and solvent phase (i.e. a chemical with high Pow is rather ‘pushed out of the water’ than ‘pulled into octanol’). This explains the poor correlation typically observed between octanol solubility and Kow (Dearden, 1990, Sijm et al., 1999). The ratio was found somewhat more representative if one uses octanol/saturated water and water/saturated octanol. - GLP compliance:
- no
- Type of method:
- other: calculated
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- <= -0.858
- Temp.:
- 20 °C
- pH:
- 10
Reference
n-Octanol solubility of the test item: 55.43 g/L at 20 °C
Water solubility of the test item: >= 400 g/L at 20 °C (pH 10)
Pow =< 55.43/400 = 0.139; log Pow =< -0.858.
Description of key information
log Pow =< -0.858 at 20 °C, pH 10
Key value for chemical safety assessment
Additional information
The partition coefficient of the substance was determined using calculation method according to OECD 107 (EU A.8).
The method is based on measured solubility values in water and in n-octanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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