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EC number: 689-137-0 | CAS number: 247569-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 2012 - August 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- EC Number:
- 689-137-0
- Cas Number:
- 247569-56-8
- Molecular formula:
- C8 H7 F O4 S
- IUPAC Name:
- 2-fluoro-5-methanesulfonylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- BMG sample no. M1302-01397-01
Lot no. 270002C
CAS no. 247569-56-8
Purity 99.86%; treated as 100% pure
Water solubility Soluble
Test substance storage At room temperature, protected from light
Retest date 20 February 2014
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Any other information on results incl. tables
Cell concentrations (OD680) are presented in Table 2. The biomass increase is depicted in Figure 1.
The average specific growth rates over 3 days and the respective inhibition percentages are presented in Table 3. The section-by-section (days 0–1, 1–2 and 2- 3) specific growth rates are presented in Table 4.
The average yield over 3 days and the respective inhibition percentages are presented in Table 5. The test concentrations are presented in Table 6, whereas the physico-chemical data are indicated in Table 7.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The median growth inhibiting concentration (ErC50/EyC50) and the low-effect concentrations (ErC10/EyC10,ErC20/EyC20), based on the average specific growth rate and the yield (algal biomass production) within 3 days, of 2-Fluoro-5- (methylsulfonyl)benzoic acid to the green alga Desmodesmus subspicatus, were investigated over a period of 72 h.
Since 2-Fluoro-5-(methylsulfonyl)benzoic acid is soluble in water, a stock solution of the test material in algal medium was prepared. Test concentrations were prepared by dilution of this stock solution. The test substance concentrations were 12.5, 25, 50, 100 and 200 mg/l. Three parallel test vessels were used for each nominal test concentration.
HPLC analysis of 2-Fluoro-5-(methylsulfonyl)benzoic acid was performed at the beginning and after 24, 48 and 72 h of exposure. Measured concentrations at the beginning of the exposure were 12.0, 24.1, 47.2, 91.3 and 162 mg/l. The concentrations were satisfactorily maintained over the whole exposure period. Geometric mean concentrations over a period of 72 h (GM0-72h) were 12.1, 24.1, 45.5, 86.7 and 164 mg/l (101, 100, 97, 95 and 101% of initial concentration, respectively).
The median effect concentration with respect to growth rate (ErC50/0-3 days) of 2- Fluoro-5-(methylsulfonyl)benzoic acid to Desmodesmus subspicatus was estimated to be >164 mg/l geometric mean concentration (GM0–72h).
The low effect concentrations with respect to growth rate, ErC10 and ErC20, were estimated to be >164 mg/l geometric mean concentration (GM0-72h), respectively.
The no observed effect concentration (NOErC) with respect to growth rate was determined to be 164 mg/l geometric mean concentration (GM0-72h).
The median effect concentration with respect to yield (EyC50/0–3 days) of 2-Fluoro- 5-(methylsulfonyl)benzoic acid to Desmodesmus subspicatus was estimated to be >164 mg/l geometric mean concentration (GM0–72h).
The low effect concentrations with respect to yield, EyC10 and EyC20, were estimated to be >164 mg/l geometric mean concentration (GM0-72h), respectively.
The no observed effect concentration (NOEyC) with respect to yield was determined to be 164 mg/l geometric mean concentration (GM0–72h). Algal growth stimulation was observed at all test concentrations.
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