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Diss Factsheets
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EC number: 700-692-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
(Full justification for cross-reading can be found in the document attached to Chapter 13 of this IUCLID: "Category approach justification for polyamine acetates 29 03 2012.pdf".)
Data is based on read across from a structurally similar branched triamine C12. Branched triamine C16-18 (tallow) only differs in the length of the alkyl chain, which is suspected to influence aspects related to bioavailability, but not of chemical reactivity and route of metabolisation, that influence specific mechanisms of toxicity relevant for genotoxicity. For these reasons, many of the studies can be performed on the substance with the shortest chain length within a group of structurally similar substances, as this is considered to represent the most sensitive species to show specific effects.
The test substance was found non-mutagenic in a bacterial mutagenicity test (Ames test), performed in accordance with EU Method B.13/14 and under GLP, with Salmonella typhimurium strains TA 1535, TA 1537, TA100, TA98, and TA102 using test concentrations up to 200 μg/plate, both with and without metabolic activation (CIT, 2002d). The tests were performed up to cytotoxic levels. Two independent experiments were performed, using 3 plates per dose level. No increased number of revertants was observed in any experiment, indicating that the substance is not mutagenic in the Ames test.
As the acetate will dissociate from the substance during the process of absorption, there is no principal difference between systemic exposure to the polyamines acetate and the polyamine without the acetate. Consequently, cross-reading with the above mentioned study is applied for this endpoint to N-(3-aminopropyl)-NN-(C16-18 evennumbered, 18 unsaturated)-alkylpropane-1,3-diamine acetate. Additionally, polyamines do not react with DNA or react to protein (indicated by OECD Toolbox profiling).
Short description of key information:
All bacterial strains showed negative responses over the entire dose range, i.e. no significant dose-related increase in the number of revertants in two independently repeated experiments. The results are read acrossed from N-(3-aminopropyl)-N-tallow alkyl trimethylene diamine (N-(3-aminopropyl)-N-C12-18 alkyl trimethylene diamine, CAS#.85632-63-9. Read across is justified by structural similarities.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Available information from bacterial mutagenicity studies on the corresponding polyamine shows no signs of genotoxicity.
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