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EC number: 247-384-8
CAS number: 25973-55-1
The number of implantations was slightly reduced, and incidence of
preimplantation loss was slightly increased in the high-dosage group, a
finding associated with the tendency for reduced maternal body weight
gain during the administration period, with an increase in maternal body
weight gain after completion of the administration period. These
differences were probably associated with
the variability in litter sizes in the high-dosage group and unrelated
to the administration of the test chemical. No significant changes in
any maternal parameters were noted, even at 1000 mg/kg. No significant
changes in embryonic/fetal survival or growth parameters were found,
even at 1000 mg/kg. These findings indicate that DBHCB is not toxic to
maternal animals, embryonic/fetal survival, or fetal growth when
administered during the time of implantation to the term of pregnancy.
Morphological examinations in the fetuses of exposed mothers revealed no fetuses
with external malformations. However, some fetuses with skeletal and/or
internal variations were found in all groups. The variations observed in
the current study are of the types that occur spontaneously among the
control rat fetuses (Kameyama et al., 1980; Morita et al., 1987;
Nakatsuka et al., 1997;
Barnett et al., 2000). A skeletal variation (i.e., full supernumerary
ribs) has been described as a warning sign of possible teratogenicity
and is known to occur in the presence of perturbation of maternal
homeostatis. All other variations, short supernumerary ribs, sternebral
variations, and bilobed centra of the vertebral column, are frequent
variations, which were considered to be normal findings.
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