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Diss Factsheets
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EC number: 245-883-5 | CAS number: 23783-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Scientifically reliable study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,6,9,12-tetraoxotridecanol
- EC Number:
- 245-883-5
- EC Name:
- 3,6,9,12-tetraoxotridecanol
- Cas Number:
- 23783-42-8
- Molecular formula:
- C9H20O5
- IUPAC Name:
- 2,5,8,11-tetraoxatridecan-13-ol
- Test material form:
- liquid
- Details on test material:
- - Physical state: colorless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Box reason, conventional breeding
- Age at study initiation: 3 - 5 Months
- Weight at study initiation: 2.1 - 2.5 kg
- Housing: in a fully air-conditioned rooms in individual cages (Battery cages)
- Diet: Altromin 2123 maintenance diet - rabbit Altomin GmbH, Lage / Lippe, ad libilum and hay (approximately 15g per day)
- Water: deionized, chlorinated water from automated watering ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20 +/- 3 °C
- Humidity: 50 +/- 20%
- Photoperiod: 12 hours a day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml of the undiluted substance.
- Duration of treatment / exposure:
- 4 hours.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Approximately 24 hours prior to the experiment start 3 rabbits in the dorsal region were of trunk with an electric hair clipper with an area of approximately 25 cm2 depilated. Only animals with intact skin were used.
- Type of wrap if used: Each animal was given a wound plaster with 2.5 x 2.5 cm coarse pulp edition (special design the company, Beiersdorf AG, Hamburg) were prepared and fixed on the skin site. Area was then covered with a semiocclusive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the remaining was test substance was gentlyremoved with tap water.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Individual animal data are not reported as there were no effects seen from 24 hour observation and beyond
Any other information on results incl. tables
One hour after removal of the patch was barely visible on two animals. Erythema observed. 24 hours after the administration no symptoms of irritation were observed.
Time after removal of patch | 1 hr | 24hr | 48hr | 72hr |
Animal number | 1 2 3 | 1 2 3 | 1 2 3 | 1 2 3 |
Erythema and Eschar | 1 1 0 | 0 0 0 | 0 0 0 | 0 0 0 |
Oedema | 0 0 0 | 0 0 0 | 0 0 0 | 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a guideline skin irritation study, the substance methyl tetraglycol caused no irritation over the observation period 24 -72 hours following application of the substance.
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