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Diss Factsheets
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EC number: 295-322-3 | CAS number: 91995-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methoxy-2-methylbutane
- EC Number:
- 213-611-4
- EC Name:
- 2-methoxy-2-methylbutane
- Cas Number:
- 994-05-8
- Molecular formula:
- C6H14O
- IUPAC Name:
- 1,1-dimethylpropyl methyl ether
- Details on test material:
- - Name of test material; MRD-89-374
- Description: the test material was a colourless liquid which was assumed to be sufficiently pure for purposes of dosing
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles river
- Age at study initiation: 8-11 weeks
- Weight at study initiation: 200-350 gram
- Fasting period before study: overnight prior to dosing
- Housing: 5 per cage/per sex/per dose
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature: 68-76 degrees Farenheit
- Humidity (%): 40-70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1989-03-28 To: 1989-04-11
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- vehicle: none
exposure: by oral intubation via syringe and a No. 13 stainless steel straight, ball-tipped feeding needle
- Doses:
- 2000, 2500 and 3000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- The dose range was based on a range-finding study. Clinical observations were recorded at 1, 2, 4 and 6 hours after dosing and once daily for 14 days after dosing. Body weights were recorded on the day before dosing, the day of the dosing (day 0), day 7 and day 14 and at termination followed by a gross necropsy.
- Statistics:
- The body weights were analysed using standard deviations.
The LD50-value was calculated using the Litchfield-Wilcoxon method with equal weighing of the data points.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 417 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 602 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 152 mg/kg bw
- Mortality:
- Four animals died in the 2000 mg/kg bw group, seven animals in the 2500 mg/kg bw group and eight animals in the 3000 mg/kg bw group. One animal was found dead on day 0 but this was thought to have resulted from a dosing error. The animal was replaced by another.
- Clinical signs:
- other: Clinical observations showed typical signs of sedation and included, for example, ataxia, emaciation, prostration, hypothermia, hypoactivity, dyspnea, hypopnea, wet and dry rales, both clear and red nasal and oral discharge, staining of the fur and piloer
- Gross pathology:
- The animals that died showed in gross necropsy abnormalities of the gastro-intestinal tract and the urinary bladder, discolouration of the thymus, lungs and liver and staining of the fur. There was a single incident of enlarged heart atrium and one of dilated pelvis in both kidneys. Surviving animals had no observable abnormalities apart from a single incidence of dilated kidneys and one liver abnormality in the 2500 mg/kg bw group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.