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EC number: 406-420-4 | CAS number: 69430-40-6 DC 5067
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 7 - March 19, 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- EC Number:
- 406-420-4
- EC Name:
- α-trimethylsilanyl-ω-trimethylsiloxypoly[oxy(methyl-3-(2-(2-methoxypropoxy)propoxy)propylsilanediyl]-co-oxy(dimethylsilane))
- Cas Number:
- 69430-40-6
- Molecular formula:
- Unspecified example: C18.3H46.8O5.8Si4.1
- IUPAC Name:
- 2,2,4,4,6,12,15-heptamethyl-6-[(trimethylsilyl)oxy]-3,5,10,13,16-pentaoxa-2,4,6-trisilaheptadecane
- Details on test material:
- - Name of test material (as cited in study report): DC 5067
- Substance type: Reaction mass (mixture)
- Physical state: Liquid
- Analytical purity: > 99%
- Lot/batch No.: AB 090122
- Expiration date of the lot/batch: December 1, 1991
- Stability under test conditions: Stable
- Storage condition of test material: In the original container at room temperature in the dark
- Other:
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- The test substance (0.1 ml per animal) was instilled in the conjunctival sac of the right eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second to prevent loss of the test substance. The other eye remained untreated and served as the reference control.
- Observation period (in vivo):
- The eyes of each animal were examined approximately 1, 24, 48 and 72 hours after instillation of the test substance.
- Number of animals or in vitro replicates:
- 3 (females)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Draize score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, 72 hrs
- Score:
- >= 0 - <= 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: No occular corrosion, no signs of systemic intoxication
- Irritation parameter:
- overall irritation score
- Remarks:
- Draize score
- Basis:
- animal #2
- Time point:
- other: 1, 24, 48, 72 hrs
- Score:
- >= 0 - <= 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hrs
- Remarks on result:
- other: No occular corrosion, no signs of systemic intoxication
- Irritation parameter:
- overall irritation score
- Remarks:
- Draize score
- Basis:
- animal #3
- Time point:
- other: 1, 24, 48, 72 hrs
- Score:
- >= 0 - <= 6
- Max. score:
- 6
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: No occular corrosion, no signs of systemic intoxication
- Other effects:
- No other effects observed.
Any other information on results incl. tables
Irritation:
Instillation of DC 5067 into one of the eyes of each of three albino rabbits affected the conjunctivae of all animals. The irritation of the conjunctivae was reversible within 48 hours in all animals. Treatment of the eyes with 2% fluorescein, 24 hours after test substance instillation revealed no cornea1 epithelial damage in all of the animals.
Colouration:
No staining by the test substance was observed.
Corrosion:
There was no evidence of ocular corrosion.
Toxic Symptoms / Mortality:
No toxic symptoms were observed in the animals during the test period and no mortality occured.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Draize score: 3.3, Kay and Calandra rating: M1 Criteria used for interpretation of results: other: Draize score (Draize et al., J. Pharmacol. Exp. Ther. 82, 1944)
- Conclusions:
- DC 5067 should be considered minimally irritating (Ml) to the rabbit eye (Kay and Calandra interpretation of the Draize score : 3.3).
- Executive summary:
The purpose of this study was to assess the possible irritation or corrosion potential of DC5067 when a single dose of DC5067 was placed in the conjunctival sac of a rabbit eye.
This study was carried out in accordance with OECD Guideline Number 405, "Acute Eye Irrittion/Corrosion" and EEC Directive 84/449/EEC, Part B.5, "Acute Toxicity-Eye Irritation". DC5067 was instilled in one of the eyes of each of three female rabbits, followed by four observations at approximately 1, 24, 48, and 72 hours after test article administration.
Under the conditions of this study, DC5067 resulted in adverse effects of the conjunctivae in all three animals. The irritation of the conjunctivae was reversible within 48 hours in all animals. No ocular corrosion was observed in any of the animals. No signs of systemic intoxication were observed during the study period.
The test substance should be considered minimally irritating (Ml) to the rabbit eye (Kay and Calandra interpretation of the Draize score: 3.3).
According to the EEC criteria for classification and labelling requirements for dangerous substances (EEC Directive 83/467/EEC, Annex VI of the EEC Council Directive 67/54B/EEC, DC5067 need not be labelled as an eye irritant.
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