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Diss Factsheets
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EC number: 459-330-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03/09/04 - 28/10/05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- EC Number:
- 609-858-6
- Cas Number:
- 406-78-0
- Molecular formula:
- C4H3F7O
- IUPAC Name:
- 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling: Frequency –
First limit test: ca. 26 hours following the start of dosing, samples were taken from the 221 mg/l limit concentration to check the actual exposure concentration before the start of exposure. First and second limit test: at the start, after 48 hours and at the end of the 96-hour test period samples were taken from the blank-control and 221 mg/I.
Volume - 10ml from the approximate centre of the test vessel.
Storage - Samples taken after 48 and 96 hours of exposure were stored in a deep-freeze.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutions were derived from the test item, which was of 99.985% purity.
Test organisms
- Test organisms (species):
- Cyprinus carpio
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 20 - 24°C
- pH:
- 6 - 8.5
- Dissolved oxygen:
- 60%
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 76 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality was recorded in the range-finding test (which was a static method), and the recovery of the test item was low. Therefore for subsequent tests, a flow-through method was used to ensure that nominal concentrations were reached.
The 1st limit test reached concentrations of 73 mg/l, which is below the 20% threshold for limit tests (100 mg/l). No mortalities were observed during this study.
in the 2nd limit test, a mean of 76 mg/l was achieved across the 3 days of exposure, reaching as high as 85.6 mg/l. Precipitation was observed in the test environment. A total of 2 fish died during this test, which is below 50% of the median number of fish (total number of fish was 7)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the flow-through conditions of the present test 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether induced less than 50% mortality in carp at a mean measured test concentration of 76 mg/I, the highest exposure concentration that could be achieved and maintained stable in tap water.
Based on the observations of precipitate in the form of droplets in both limit tests, it cannot be excluded that fish were, at least occasionally, exposed to pure test substance.
In conclusion, the 96h-LC50 exceeded a mean measured concentration of 76 mg/I. - Executive summary:
The test substance 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether was evaluated for acute toxicity in fish in an OECD 203 study. Initially, a static test was proposed, however this was changed to a flow-through test following poor recovery of the test item from the testing environment.
During subsequent flow-through tests, it was still difficult to maintain nominal concentrations, and in the final study, a mean concentration of 76 mg/l was obtained. During this final test, 2 mortalities occurred, and it was noted that the fish seemed disorientated during the 96 hours.
As 50% mortality was not observed, the LC50 is considered to be >76 mg/l.
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