Registration Dossier
Registration Dossier
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EC number: 413-920-6 | CAS number: 88949-33-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish. No toxic effects occur within the range of solubility.
Key value for chemical safety assessment
Additional information
Two static limits test were performed according to the OECD guideline 203 using zebra fish (nano form) and carp (bulk form).
Due to the low water solubility of the test substance a dispersion (96 h saturation) with the loading rate of 100 mg/L was tested (RCC Ltd. 2008) using the nanoform. The undiluted filtrate without solvents or emulsifier was used. No effects within the range of solubility could be observed. The NOEC/LC0 (96 h) was determined to be at least the loading rate of 100 mg/L. The LOEC, LC50 and LC100 were clearly above the loading rate of 100 mg/L.
A second test with carp using the bulk form was conducted. Two different test solutions were used. A supersaturated solution of 100 mg/L dispersed with Cremophor RH 40 and additionally a filtrate of the supersaturated solution (RCC NOTOX 1993c). The supersaturated solution is a maximum dispersion due to the use of Cremophor RH 40. Since undissolved test material was observed that allowed exchange within the test system of soluble and dispersed particles, it is a worst case consideration for the bulk and the nano form since both forms have a similar behavior in environmental media according to the results of the OECD 318 guideline studies. No effects occurred using both test solutions, even though undissolved material was observed in the supersaturated solution. The 96-hour LC50 was determined to be higher than the loading rate of 100 mg/L. The LC0 and LC100 are both higher than 100 mg/L. No mortality or visible abnormalities were observed during the test period of 96 hours for the supersaturated solution and the filtrate.
Therefore, it can be stated that the nano and the bulk are with high probability acutely not harmful to fish.
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