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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 22 - May 30, 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- For the preparation of the highest test concentration, 100 mg of the test item was transferred
into a glass flask, which was filled up 1000 mL dilution water.
The test media was stirred vigorously for about 2 hours at room temperature. The other test
concentrations were prepared by serial dilution - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISMS:
Source:
- German Federal Environment Agency, Institut für Wasser-, Boden- und
Lufthygiene. Specimens used in the test are bred in the laboratory of the Fraunhofer IME.
- Age: juvenile Daphnia magna, 4 – 24 hours old. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 – 350 mg CaCO3/L
- Test temperature:
- 18.9 and 19.2 °C
- pH:
- 8.11 – 8.28
- Dissolved oxygen:
- 6.30 - 9.09 mg/L
- Nominal and measured concentrations:
- The concentrations tested in the definitive test were selected based on results from the
range-finding tests.
Concentrations:
Control, 6.25, 12.5, 25.0, 50.0 and 100 mg test item/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers (50 mL)
- Fill volume: 50 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Purified drinking water.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 h day-night regime
- Light intensity: 765 - 802 Lx
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mobility after 0, 24 and 48 h
TEST CONCENTRATIONS
- Range finding study: 1, 10 and 100 mg test item/L
- Test concentrations definitive test: Control, 6.25, 12.5, 25.0, 50.0 and 100 mg test item/L - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Mortality of control: no - Reported statistics and error estimates:
- There was no immobility of daphnids up to and including the highest test item concentration
applied. Consequently, no statistic effect evaluation could be applied. - Validity criteria fulfilled:
- yes
- Conclusions:
- Based on nominal concentrations, the EC50 for immobility can be given as > 100 mg test item/L and the NOEC can be given as ≥ 100 mg test item/L.
- Executive summary:
A study was performed to investigate the influence of the test item on the mobility of Daphnia magna according to the OECD 202.
Based on nominal concentrations, the EC50 for immobility can be given as > 100 mg test item/L and the NOEC can be given as ≥ 100 mg test item/L.
Reference
Description of key information
Not acutely toxic to aquatic invertebrates
Key value for chemical safety assessment
Additional information
The acute toxicity of test item to aquatic invertebrates was investigated in a study conducted according to OECD guideline 202. Daphnia magna were exposed to nominal test substance concentrations of 6.25, 12.5, 25.0, 50.0 and 100 mg test item/L for 48 hours. The concentrations of the test item in the media were confirmed by measurements of the test item at beginning of the test and at test end using a LC-MS/MS system.
An immobilization of the Daphnids was not observed at any tested concentrations. The EC50 is > 100 mg test item/L, the NOEC is ≥ 100 mg test item/L.
Based on the experimental results the test item is not acutely toxic to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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